Aducanumab and Lecanemab: How are they different?

Author

Kathleen Warshawsky, BSN, RN

For more information about the author, click to view their website: Kathleen Warshawsky

Posted on

Feb 06, 2023

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Non-Book Market , Texas - Dallas, Collin, SE Denton & Rockwall Counties

Aducanumab and Lecanemab: How are they different?

Aducanumab and Lecanemab are both medications for the treatment of Alzheimer's disease. Aducanumab is a monoclonal antibody that targets beta-amyloid, a protein that accumulates in the brain and is associated with the development of Alzheimer's. Lecanemab is also a monoclonal antibody but it targets a different structure of beta-amyloid, called N3pG, which is believed to play a key role in the formation of amyloid plaques in the brain.

The main difference between Aducanumab and Lecanemab is their mechanism of action. Aducanumab works by removing beta-amyloid from the brain, while Lecanemab works by blocking the formation of amyloid plaques in the brain.

In clinical trials, Lecanemab has been shown to remove amyloid more quickly than Aducanumab or another medication called gantenerumab. Lecanemab has also shown a lower incidence of a side effect called ARIA (amyloid-related imaging abnormalities) compared to Aducanumab in clinical trials.

It is important to note that both medications are still under investigation and more research is needed to fully understand their benefits and limitations. The choice of medication will ultimately depend on a patient's specific needs and circumstances, and should be made in consultation with a healthcare provider.

Additionally, Aducanumab is approved for use in some countries, including the U.S., but is still awaiting approval in others. Lecanemab as of January 6th, 2023, has been approved by the U.S. Food and Drug Administration (FDA) through the Accelerated Approval pathway.

Both Aducanumab and Lecanemab are part of a growing body of research into new treatments for Alzheimer's disease, which remains one of the most challenging and devastating neurological conditions. There are currently limited treatment options for Alzheimer's, and the development of new and effective therapies is a major priority for researchers and clinicians.

While both medications show promise in their ability to target beta-amyloid, it is important to remember that treating Alzheimer's is a complex process that involves addressing multiple factors, including genetics, lifestyle, and environment.

In conclusion, the differences between Aducanumab and Lecanemab lie in their mechanism of action and stage of development. Further research is needed to determine the long-term safety and efficacy of these medications in the treatment of Alzheimer's disease. As with any medical treatment, it is important to consult with a healthcare provider to determine the best course of action for an individual patient.


Author:  Kathleen Warshawsky, RN, BSN | Publisher Seniors Blue Book | https://www.linkedin.com/in/kathleenwbsnrn/

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Aducanumab and Lecanemab: How are they different?

The Success of Lecanumab (Leqembi) in Treating Alzheimer's Disease

The Success of Aducanumab in Treating Alzheimer's Disease


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Lets talk PATHWAYS: Personalized Support for Those Experiencing Cognitive Decline

Lets talk PATHWAYS:  Personalized Support for Those Experiencing Cognitive DeclineDecember 5, 2024 By CC Young StaffThis time of year is filled with gatherings, which means you may be spending more quality time with your family members, particularly your parents and older relatives. While time spent together is a blessing, it can also highlight changes brought on by aging. If you believe someone you love is experiencing mild cognitive decline, there are options for keeping them safe while maintaining their independence and quality of life.This year, CC Young Senior Living in Dallas launched the Personal Assistance Toward Health and Wellness As You Succeed (PATHWAYS) program. Designed to serve as a bridge between Assisted Living and Memory Support, PATHWAYS provides extra support and structure in an intimate, small-group setting.We sat down with Nena Paris, CC Youngs Administrator, Assisted Living and Memory Support, to better understand the PATHWAYS program and who can benefit from it. Here are seven takeaways.PATHWAYS was created to fill a need between Assisted Living and Memory Support. The program came about because, often, Memory Support units can have long waitlists and fill up quickly. Truthfully, sometimes people with cognitive impairment dont necessarily need full Memory Support, as theyre not at risk of eloping, or leaving the community without supervision. CC Young has recognized that theres this middle group people who need a little more guided assistance and structure with their daily activities but are not qualified for full-blown Memory Support.PATHWAYS can actually slow cognitive decline. Research has shown that a guided program like PATHWAYS can in fact slow cognitive decline and help people stay engaged. Our program does this by providing residents with personal interaction, along with physical and emotional support, as a way to enhance their overall wellness and quality of life in a positive environment.PATHWAYS promotes resident wellness. At CC Young, we focus on whole-person wellness, using the 7 Pillars of Wellness as defined by the International Council on Active Aging: physical, social, spiritual, intellectual, emotional, vocational, and environmental wellness. Thats also the backbone of the PATHWAYS program, which promotes active aging regardless of cognitive issues. From these pillars, we have designed a comprehensive therapeutic program to support the needs of those with mild cognitive impairment in a joyful, engaging environment.PATHWAYS offers an intimate caregiver-to-resident ratio. Part of what makes PATHWAYS so successful is that the CC Young staff works closely with residents, which means the staff will notice any cognitive changes. In fact, at 1 caregiver to 7 people, the caregiver-to-resident ratio in PATHWAYS is better than both Assisted Living and Memory Support, which are 1 to 25 and 1 to 10, respectively. That also results in PATHWAYS residents becoming like family, as the staff truly gets to know them.PATHWAYS is not just for CC Young residents. Its true anyone from the Dallas community who has a need for the program can become a PATHWAYS resident. Upon entering the PATHWAYS program, your family member would also become an Assisted Living resident in The Hillside at CC Young.PATHWAYS is a less stressful transition for both family members and residents. It can certainly be stressful for families to face the decision of whether or not their family member should enter Memory Support. PATHWAYS offers a comforting solution for both them and their loved ones, as it lessens the pressure of deciding whether full Memory Support is needed now. The PATHWAYS resident may be able to live out their days in the PATHWAYS program or eventually transition to Memory Support, if the need arises.PATHWAYS keeps residents engaged and prevents isolation. To keep PATHWAYS residents engaged, the program takes an active and intentional approach to life enrichment activities, which includes participating in activities on the Assisted Living calendar as well as a specialized PATHWAYS calendar. The biggest differentiator for PATHWAYS is that a dedicated support staff member helps residents plan their day and escorts them to the activities. Since we purposely guide residents to keep them engaged, they are able to remain active and enjoy a better quality of life, while also avoiding any isolation that can be a symptom of cognitive decline.PATHWAYS is just one more service that CC Young offers current and prospective residents and their families. When we noticed an increase of older adults experiencing various levels of cognitive decline but not necessarily to the level of needing Memory Support we wanted to do something about it. We put our heads together and created a solution: PATHWAYS.If you are noticing cognitive decline in someone you love, we encourage you to have a conversation to express what youre observing. Talking to your primary care physician is a good place to start. CC Young is also happy to provide information, so feel free to give us a call at 214-305-9662.

A Comprehensive Guide to Supporting Aging at Home

Aging in place is becoming increasingly important for many American families. According to an AARP survey, more than half of Americans aged 50 and older plan to remain in their homes throughout their aging journey. And its no surprise whyaging at home offers familiarity, comfort, and, with proper planning, can be a more economical option that promotes independence for longer.However, the decision to age in place comes with its own set of challenges, particularly financial ones. Rising healthcare and long-term care costs make early and open financial planning crucial for families.If your parent or loved one is considering aging at home, this guide offers practical tips to support their independence while avoiding unnecessary financial strain.1. Start the Money Conversation EarlyTalking about finances with aging parents can be uncomfortable, but its an essential step to ensure their comfort and security. Approach this discussion with empathy and openness, focusing on how you can work together to maintain their quality of life.Here are key topics to cover:Income Sources: Discuss pensions, Social Security benefits, and retirement savings like 401(k)s or investments.Monthly Expenses: Understand their current spending and where adjustments might be needed.Future Costs: Highlight potential costs like home modifications, in-home care, and medical expenses.Creating a clear picture of their financial standing helps families plan effectively and reduces future stress.(Need help starting this discussion? Check out our blog, Tips for Convincing Aging Parents to Accept Help.)2. Understand the Costs of Aging in PlaceWhile aging at home is often more affordable than senior living facilities, its not without significant costs. For context, senior facilities can cost $4,500 to $5,300 per month on average, according to the National Council on Aging.Aging at home avoids some of these expenses, but families should still anticipate:Home Maintenance and Modifications: An AARP study revealed that 52% of out-of-pocket costs for aging at home go toward maintenance and accessibility updates, such as grab bars, ramps, or stairlifts.In-Home Care: Costs for personal care or medical support staff vary depending on the level of assistance needed.Medical Emergencies: Unexpected healthcare needs, especially for conditions like dementia, can lead to surprise expenses.Understanding these costs early allows families to budget appropriately and avoid financial shocks.3. Explore Long-Term Care InsuranceGiven the high cost of long-term care, investing in a long-term care insurance policy may be worth considering. These policies can cover in-home care, nursing services, or assisted living facilities, reducing financial stress when care needs arise.Timing Matters: The earlier you purchase a policy, the more affordable it will be.Evaluate Carefully: Not all policies cover every type of care, and premiums can be expensive.If insurance isnt an option, families can explore alternative strategies, such as hybrid insurance plans that combine life insurance with long-term care benefits.4. Prioritize Home Safety ModificationsCreating a safe living environment is key to helping your parent stay independent at home. Start with basic home modifications:Install grab bars in bathrooms.Add ramps or stairlifts for improved mobility.Ensure good lighting throughout the home to reduce fall risks.These changes can cost anywhere from a few hundred to several thousand dollars but are crucial for safety and peace of mind.Beyond modifications, consider investing in medical alert systems or fall-detection technology to provide an added layer of security.5. Plan for In-Home Care NeedsAs your parent ages, their care needs may increase. Early planning ensures that youre ready for the transition:Start Small: Part-time help from a home health aide may suffice initially, covering tasks like meal preparation or light housekeeping.Scale Gradually: If full-time or overnight care becomes necessary, families should prepare for costs that can exceed $100,000 annually.For lighter support, consider intermediary services like Naborforce, which connects aging adults with Nabors who assist with everyday tasks, such as transportation and grocery shopping. These services can extend independence and delay the need for more intensive care.6. Understand Medicare, Medicaid, and Additional ResourcesNavigating government programs can be daunting but essential for offsetting care costs:Medicare: Covers limited short-term in-home care, typically after a hospital stay, but not long-term care.Medicaid: Offers comprehensive coverage for long-term care, though eligibility is income-based and requires a detailed financial review.Additionally, research state-level programs, veterans benefits, or caregiver compensation opportunities that may be available in your area.7. Stay Flexible and Plan for the UnexpectedEven with careful planning, caregiving can come with unexpected twists, from sudden health changes to financial surprises. Build a cushion into your budget to account for emergencies and remain flexible in your approach.Helping your loved one age comfortably at home requires careful planning, open communication, and the right resources. By addressing finances early, making necessary home modifications, and utilizing services like Naborforce, families can create a supportive environment that fosters independence and comfort.Aging at home is not just a choice; its a commitment to ensuring your parents dignity and quality of life. With a solid plan in place, you can navigate this journey together, providing your loved one with the care and security they deserve.And when you need a helping hand, remember that Naborforce is here to support you every step of the way.A Helping Hand for Older Adults - Naborforce 844-696-2267 Were Naborforce. We match older adults who need a little help and kindness with Nabors eager to provide it, strengthening the communities we serve. Everyone can use a little help. Help around the house. Help running errands. Help preparing a meal. Help by just being a friend! Our goal is to promote joyous and independent aging and living while providing peace of mind to families.

A Place to Age with Grace: AltaVita Senior Living Residences

AltaVita Senior Residences is a dream come to fulfillment for the Macy Family. The longtime Longmont locals desired a way to give back to the community in which they grew up. And what better way to deliver on that commitment than to provide a multigenerational housing opportunity for Colorado families: three levels of continuing senior care on one campus in an unmatched, upscale environment. Filling a niche for older folks who want a place to call home for years to come, AltaVita has thought of every lifestyle element that seniors desire and deserve in an adult living community. Here a foundation for a brighter future is built on a unifying philosophy: Always put the resident first. This means providing for all aspects of the aging process 24 hours a day, 365 days a year. People are living longer and healthier lifestyles, and theyre remaining active, says Linda Berens, the campus Executive Director. Because of that many are looking for a multi-tiered campus offering continuing care within the familiar lifestyle. From involving family members in each residents life to creating a secure residence for those with advanced memory-related illnesses, AltaVitas well-designed campus and comprehensive services are built from the ground up to address and enhance every moment of daily living. One AltaVita residents family member said it best recently: I cant truly convey the appreciation I have for all that you have done. You have all been such a blessing to my mom and our family. The AltaVita team holds one another to a higher standard, which honors the important work they do, assisting the people who need them most. Enrich and enhance the lives of everyone we serve with respect and excellence: the AltaVita mission is confirmed daily by all the smiling faces. Three levels of care on one campus AltaVitas Longmont campus consists of the Memory Care Community, which opened in 2012; the Assisted Living Community, which followed in 2016; and the Independent Senior Living Community, which opened in June 2019. By building the community in three phases, planners have been able to thoughtfully design each building with residents in mind, taking into consideration the type of care they need and the amenities that will best suit them, explains Don Macy, owner.Memory Care Dr. Haleh Nekoorad-Long, M.D., a certified geriatric psychiatrist, is the medical director of AltaVita Senior Residences and works primarily with aging adults and issues regarding dementia, depression, and bipolar disorder. Recognized by the Alzheimers Association as a Leader in Dementia Care, the AltaVita Memory Care Centre is setting a new standard in Colorado for exceptional care for people with memory-related issues. AltaVita Memory Care Centre runs an adult day program, with respite services in suites specially designed for residents with Alzheimers and dementia. Additionally, care is customized for every residents level of dementia, ranging from acute medication management to the sense of freedom that comes with visiting AltaVitas beautiful garden patios and spacious, secure courtyard.Assisted Living With access to the same welcoming outdoor landscape, the AltaVita Assisted Living Community offers an upscale service focused intention. On the main level a great room welcomes visitors with a cozy fireplace, tavern, bistro and ice-cream parlor, and plentiful seating areas. The second floor overlooks the great room and features a large community room for varied activities as well as a comfortable lounge. Inclusive to the Assisted Living lifestyle are three meals every day, housekeeping and laundry services, social and recreational activities, 24-hour staffing, medical transportation, and emergency and nurse call systems. Independent Senior Living This is AltaVitas newest addition to the campus, a community for active adults who would like the enrichment of community life free of the responsibilities of home repairs. This maintenance-free lifestyle, including housekeeping, dining and transportation services, is designed to maximize that freedom and minimize those pesky daily duties. The new three-story building contains 84 stylish apartments with nine different floor-plan designs ranging from one bedroom, one bath to two bedrooms plus den and two baths. All include full kitchens, walk-in closets, large showers, washers and dryers, and private patios. The independent lifestyle program includes top-notch services and amenities like a full-service salon, fitness center, wellness programs, Tai chi classes, bistro and bar, housekeeping, and restaurant-style dining room. And when the outdoors beckons there is easy access to hiking, biking, and walking trails. On behalf of the family, we wish to extend our gratitude to such an excellent place for Vern to live, report family members of the experience of their loved one at AltaVita. The friendliness of the staff is beyond compare. We are very impressed with the quality and freshness of the food; the execution of meals; the presentation of such meals.Whole-life WellnessAltaVita believes one of the most important aspects of maintaining good mental and physical health among an aging population is lifestyle. And thats where AltaVita really shines. Supporting every part of the individual, AltaVita subscribes to Whole-Life Wellness. The methodology is envisioned to enhance residents health through seven critical aspects of wellness: social, emotional, spiritual, environmental, vocational, physical, and intellectual. For more information on AltaVitas progressive approach to maximizing the lifestyle of seniors, visit altavitaliving.com or call 888.745.8268 to schedule a free tour. 

Local Services By This Author

STAP (Specialized Telephone Assistive Program)

Hearing/Deaf Products , , Texas,

If You Have A Hearing, Vision Or Mobility Problems Accessing Or Using A Telephone - You May Qualify For A Free Telephone! 4 out of 5 Americans over the age of 60 have some hearing, vision or mobility loss. There is help however and it is paid for by you through a government program called STAP, Specialized Telecommunications Assistance Program, by a small charge each month on your telephone bill. Why not take advantage of a benefit youre paying for already? Contact Laura Carr, STAP to learn more about this program and show you what equipment youre eligible to receive FREE OF CHARGE! To qualify, you must be a Texas resident with a problem with vision, hearing or mobility. You are entitled to one FREE phone every 5 years. You can get a cell phone, landline, smartphone or tablet, depending on your disability. Must provide proof of residency. Acceptable forms of residency include:*  Texas Drivers License*   ID card with address*   Voters Registration card*   Letter from facility on their stationery*   Utility Bill (current - showing address)*   Vehicle registration card*   Medicaid ID*   Medicare Summary This program is for any Texas Resident that has a Vision, Hearing, Mobility- including cognitive problems.  They are entitled to FREE telephone equipment (just the device) and they have to pay their monthly charges to their telephone service provider.  Depending on their impairment, they may qualifiy for a Landline Telephone with a medical alert system; a Regular Cell Phone (where they can make calls, text, take photos including a medical alert button on the back.  If they have a hearing problem, they can receive a 2-way texting device - an Android Smart Phone or Android Tablet.  They have to provide their proof of residency for the State of Texas:  a current drivers license, Texas ID, Voters Registration Card or a Utility bill showing their name & current address & date.   Laura can assist with completing an application, take a photo of their proof of residency - attach to their signed application & send it to STAP headquarters in Austin, Texas.  The State processes their application & mails the Voucher for the equipment, directly to the Resident.  Once they receive the Voucher, they contact Laura and she will deliver the equipment that is authorized on the voucher to the Resident.  NO MONEY CHANGES HANDS. Laura Carr, STAP Specialist has worked with this program for 16 years.Contact Laura at 214-388-0088 or LauraCarr@prodigy.net

Lifeline Screening

Medical & Wellness , , ,

Dont Let a Stroke Ruin Your RetirementYour risk of stroke and cardiovascular disease increases as you age. But the good news is 80% of stroke and cardiovascular disease CAN be prevented.1 If you are age 50 or older, you should be screened.Often there arent any symptoms of a stroke before it occurs, in fact for 4 out of 5 people who have a stroke the first symptom of any illness is the actual stroke.2 But, you can take steps to find out if youre at risk.Life Line Screening is a premier provider of preventive screenings for stroke and cardiovascular disease risk. A simple appointment can identify your risk factors and provide peace of mind or early detection.Screenings are easy, painless, non-invasive and dont require any messy prep work.Life Line Screening has over 14,000 locations across the United States so you can find one close to you.Getting screened is affordable. The most popular package at Life Line Screening includes 5 screenings in 1 appointment for $149.Get the most out of your life! Find out your stroke and cardiovascular disease risk with Life Line Screening so you can be in control and do something about it.***CLICK HERE*** to schedule your appointment! A simple screening can be worth a lifetime.1 American Heart Association https://www.heart.org/en/get-involved/advocate/federal-priorities/cdc-prevention-programs2 Hackam DG, Karpral MK, et al. Most stroke patients do not get a warning, a Population Based Cohort Study. Sept. 2009. Neurology, 73, 1074-1075.