Could a headset using light and sound really help reverse Alzheimer’s? New data says yes.
Aqualane Clinical Research
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Apr 25, 2025
Florida - Southwest
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Cognito Therapeutics is gaining momentum—and $73 million in fresh funding—thanks to compelling new evidence that its neuromodulation therapy could be a game-changer for Alzheimer’s treatment.The company recently published an analysis of its phase 2 study in the Journal of Alzheimer’s Disease, and the findings are striking: Patients using Cognito’s headset daily for six months saw increases in brain white matter and slower myelin loss, compared to declines in both among placebo users.
The headset, which delivers synchronized gamma-frequency light and sound through connected glasses and headphones, is designed to stimulate brainwave activity that may help restore neural health. This non-invasive therapy aims to combat the brain changes at the root of Alzheimer’s—specifically the degeneration of white matter and the loss of myelin, which are crucial for cognitive function. “These white matter and myelin findings may have significant implications for early Alzheimer’s intervention,” said Dr. Ralph Kern, Cognito’s Chief Medical Officer. He emphasized the entorhinal cortex’s critical role in memory circuits and disease progression. CEO Brent Vaughan added that targeting these changes could help identify individuals at high risk and open doors to earlier, more effective treatment.
Cognito is gearing up to expand trials and move closer to potential regulatory approval, fueling new hope for millions living with Alzheimer’s. If you're a patient, caregiver, or provider interested in learning more, contact Aqualane Clinical Research today before enrollment closes.
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Through independence, life plan communities flip the script on aging
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Aqualane Clinical Research
Memory Screening 3200 Bailey Lane, Naples, Florida, 34105HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. 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Aqualane Clinical Research
Memory & Dementia Care 3200 Bailey Lane, Naples, Florida, 34105HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. 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Aqualane Clinical Research
Clinical Studies 3200 Bailey Lane, Naples, Florida, 34105About UsWith over 55 years of clinical research experience, Aqualane Clinical Research is committed to advancing medical science and improving lives. By leveraging our expertise in research, we dedicate ourselves to the community and the pursuit of innovative solutions for complex health challenges through the study of new medications.Our MissionWe strive to serve our community by providing cutting-edge experimental treatments for difficult-to-control and untreated neurological conditions. Through ethical, patient-centered research, we seek to develop breakthrough therapies that address unmet medical needs.What We DoAqualane Clinical Research is a leading clinical research organization specializing in the development of new treatments for a wide range of neurological and neuropsychiatric disorders. We collaborate closely with patients, caregivers, and industry sponsors to ensure the safe, ethical, and effective study of emerging therapies. Our goal is to offer hope and innovation where current treatments are limited or nonexistent.Our Commitment to Excellence50+ Years of Expertise Our experienced team of doctors and research professionals is dedicated to providing the highest level of care.100% Patient Satisfaction We are committed to guiding patients through the clinical trial process with compassion and transparency.Our Clinical Research AreasWe are actively conducting research in the following areas:Alzheimers Disease Investigating potential treatments to slow, halt, or reverse disease progression.Parkinsons Disease Developing therapies to improve quality of life and manage symptoms.Essential Tremor Exploring the genetic factors and treatment options for this movement disorder.Multiple Sclerosis Advancing treatments through biomarker analysis and cutting-edge imaging.Migraine Studying new medications to provide relief for those suffering from chronic migraine attacks.Neuropsychiatric Conditions Researching novel therapies for depression, anxiety, and psychiatric symptoms associated with neurological disorders.Get InvolvedDiscover how you can participate in a clinical study and contribute to the future of medical innovation. Our team is ready to answer any questions you may have.Meet the TeamDr. William A. Justiz, MDMedical Director, Principal InvestigatorDr. William Justiz completed his undergraduate degree at Northwestern University before receiving his medical degree from the University of Miami School of Medicine. He is board certified in neurology and is a certified physician investigator through the Association of Clinical Research Professionals.With over 20 years of research experience and specialization in degenerative diseases of the nervous system, he has been in continuous practice in Naples, Florida since 1999. He is a founding member of the clinical research program that has grown into Aqualane Clinical Research.Community outreach and service is one of the core values of Dr. Justiz and Aqualane Clinical Research. Dr. Justiz demonstrates this with his 23-year commitment to providing low-cost or free services to epilepsy patients through Epilepsy Services of Southwest Florida. In addition, he has delivered a free educational lecture series every month on all Alzheimer's topics since 2015 through the Alzheimer's Support network.Kelly E. Calistri, B.A.Chief Executive Officer, Site DirectorKelly is a native Floridian, born and raised in Central Florida. Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDMedical Advisor, Principal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. He enjoys teaching colleagues, medical residents and patients on such topics as Multiple Sclerosis and Myasthenia Gravis. In his spare time, he loves riding roller coasters with this family and playing with his two dogs.