Could a headset using light and sound really help reverse Alzheimer’s? New data says yes.

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Aqualane Clinical Research

For more information about the author, click to view their website: Aqualane Clinical Research

Posted on

Apr 25, 2025

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Florida - Southwest

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Cognito Therapeutics is gaining momentum—and $73 million in fresh funding—thanks to compelling new evidence that its neuromodulation therapy could be a game-changer for Alzheimer’s treatment.The company recently published an analysis of its phase 2 study in the Journal of Alzheimer’s Disease, and the findings are striking: Patients using Cognito’s headset daily for six months saw increases in brain white matter and slower myelin loss, compared to declines in both among placebo users.

 

The headset, which delivers synchronized gamma-frequency light and sound through connected glasses and headphones, is designed to stimulate brainwave activity that may help restore neural health. This non-invasive therapy aims to combat the brain changes at the root of Alzheimer’s—specifically the degeneration of white matter and the loss of myelin, which are crucial for cognitive function. “These white matter and myelin findings may have significant implications for early Alzheimer’s intervention,” said Dr. Ralph Kern, Cognito’s Chief Medical Officer. He emphasized the entorhinal cortex’s critical role in memory circuits and disease progression. CEO Brent Vaughan added that targeting these changes could help identify individuals at high risk and open doors to earlier, more effective treatment.

 

Cognito is gearing up to expand trials and move closer to potential regulatory approval, fueling new hope for millions living with Alzheimer’s. If you're a patient, caregiver, or provider interested in learning more, contact Aqualane Clinical Research today before enrollment closes.

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Aqualane Clinical Research

Alzheimers Research 3200 Bailey Lane, Naples, Florida, 34105

HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. Striving to make clinical trials a practical healthcare option, we provide a comfortable, caring and compassionate environment.Our founders are passionate about their contributions to the advancement of medicine and to the opportunities they provide to people searching for new treatment options. 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Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. 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DEntremont, RN, MPH, BSNInfusion NurseDarious T. Davis, M.A.Head of Business DevelopmentLaura Gold, B.S.Finance CoordinatorKarma L. Hamilton, M.S.Lead RaterBethany J.M. Henchesmoore, MBAClinical Research CoordinatorJennifer Jimenez-Perez, RN, BSNInfusion NurseCarmen L. Ojeda, M.S.Quality Assurance / Quality ControlMichelle A. O'Neill, M.S.RaterMayve SantosResearch PharmacistAlexandria L. SmithClinical Research Coordinator

Aqualane Clinical Research

Parkinsons Support & Research 3200 Bailey Lane, Naples, Florida, 34105

HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. Striving to make clinical trials a practical healthcare option, we provide a comfortable, caring and compassionate environment.Our founders are passionate about their contributions to the advancement of medicine and to the opportunities they provide to people searching for new treatment options. 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Aqualane Clinical Research

Health Screenings 3200 Bailey Lane, Naples, Florida, 34105

HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. Striving to make clinical trials a practical healthcare option, we provide a comfortable, caring and compassionate environment.Our founders are passionate about their contributions to the advancement of medicine and to the opportunities they provide to people searching for new treatment options. 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Dr. Justiz demonstrates this with his 23-year commitment to providing low-cost or free services to epilepsy patients through Epilepsy Services of Southwest Florida. In addition, he has delivered a free educational lecture series every month on all Alzheimer's topics since 2015 through the Alzheimer's Support network.Kelly E. Calistri, B.A.Chief Operating Officer, Site DirectorKelly is a native Floridian, born and raised in Central Florida. Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDPrincipal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. He enjoys teaching colleagues, medical residents and patients on such topics as Multiple Sclerosis and Myasthenia Gravis. In his spare time, he loves riding roller coasters with this family and playing with his two dogs.Micaela M. Acres, RN, BSNInfusion NurseJacqueline E. BradyCommunity Outreach Coordinator/ ReceptionMatthew B. Cagney, B.S.Clinical Research CoordinatorElena Capron, B.S.Regulatory Coordinator / Social Media CoordinatorBrittany N. Cordero, B.S.Office Manager / Human ResourcesJessica M. DEntremont, RN, MPH, BSNInfusion NurseDarious T. Davis, M.A.Head of Business DevelopmentLaura Gold, B.S.Finance CoordinatorKarma L. Hamilton, M.S.Lead RaterBethany J.M. Henchesmoore, MBAClinical Research CoordinatorJennifer Jimenez-Perez, RN, BSNInfusion NurseCarmen L. Ojeda, M.S.Quality Assurance / Quality ControlMichelle A. O'Neill, M.S.RaterMayve SantosResearch PharmacistAlexandria L. SmithClinical Research Coordinator