Could a headset using light and sound really help reverse Alzheimer’s? New data says yes.
Aqualane Clinical Research
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Apr 25, 2025
Florida - Southwest
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Cognito Therapeutics is gaining momentum—and $73 million in fresh funding—thanks to compelling new evidence that its neuromodulation therapy could be a game-changer for Alzheimer’s treatment.The company recently published an analysis of its phase 2 study in the Journal of Alzheimer’s Disease, and the findings are striking: Patients using Cognito’s headset daily for six months saw increases in brain white matter and slower myelin loss, compared to declines in both among placebo users.
The headset, which delivers synchronized gamma-frequency light and sound through connected glasses and headphones, is designed to stimulate brainwave activity that may help restore neural health. This non-invasive therapy aims to combat the brain changes at the root of Alzheimer’s—specifically the degeneration of white matter and the loss of myelin, which are crucial for cognitive function. “These white matter and myelin findings may have significant implications for early Alzheimer’s intervention,” said Dr. Ralph Kern, Cognito’s Chief Medical Officer. He emphasized the entorhinal cortex’s critical role in memory circuits and disease progression. CEO Brent Vaughan added that targeting these changes could help identify individuals at high risk and open doors to earlier, more effective treatment.
Cognito is gearing up to expand trials and move closer to potential regulatory approval, fueling new hope for millions living with Alzheimer’s. If you're a patient, caregiver, or provider interested in learning more, contact Aqualane Clinical Research today before enrollment closes.
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Passions Grow, Passions Bloom:
Passions Grow, Passions Bloom: Cultivating Wellness at Willow Valley Communities Among the most popular passions at Willow Valley Communities is gardening. And, Residents here have a wide variety of ways to indulge. Three generous gardens are situated across our sprawling 210-acre campus for Residents to use in a multitude of configurations of their choosing. Willow Valley Communities hardworking Grounds Team tills each garden in the spring and plows them in the fall, making them ready for Residents to dig right in. Whether Residents are experienced pros or novices, gardening is a wonderful way for them to get outside, enjoy nature and each other, and learn new things. Some Residents have been gardening for decades, while others have only started gardening after moving to Willow Valley Communities. In keeping with our Life Lived Forward philosophy, some Willow Valley Communities Residents take their love of gardening to deeper levels. For example, several Residents from across the country have achieved the distinction of Master Gardener. Master Gardeners are certified in their home state, and the program can take six months to a year to complete and includes a minimum of 40 hours of classroom training, a score of 80 percent on the final exam, and 50 hours of volunteer service. In another example, Residents Annabelle Simpson and Susan Kelly worked with the Penn State Extension of the Pennsylvania State University to have one of their gardens certified as an official Pennsylvania Pollinator-Friendly Garden. The stunning garden is well-known for attracting huge numbers of bees, butterflies, insects, and birds, helping our ecosystem to thrive. Residents are also able to partner their gardening skills with their desire to volunteer and give back to the Lancaster community. With the areas rich, fertile soil, and the extra special care and attention the plants receive, Residents often have an abundance of vegetables and donate them regularly. Throughout the growing season, the Solanco Neighborhood Ministries food bank receives a variety of beans, lettuce, kale, peas, carrots, eggplant, cucumbers, peppers, tomatoes, spinach, and much more from Willow Valley Communities Resident gardens. Additionally, every fall, a harvest of hundreds of pounds of sweet potatoes and butternut squash goes to the Lancaster County Food Hub, a community resource for free, nutritious food and gently used clothing. Some Residents maintain gardening plots every year just for this purpose.Annabelle Simpson and Susan Kelly Gardening time is couple time for Residents Mike and Susan Ziegler. Sue is an avid gardener, and Mike loves being outdoors supporting her gardening passion at Willow Valley Communities. They both love being together in nature, and Sue is amazed by how magical gardening can be. Its just a miracle when the seeds come up, she says. Resident Pat Mortensen challenges herself every year by growing something completely different. Once she enjoyed a robust harvest of King Tut Purple Peas, a very rare garden pea said to have been taken out of the tomb of King Tut! Resident and Master Gardener Angela Booker-White is originally from Virginia but has lived all over the country. Her interest in gardening grew as she read and learned more about it. In her plot at Spring Run, Angela grows all sorts of fruits, vegetables, and flowers and always tries something new. She has the most success with seeds she purchases from the dollar store! Angela has also learned how gardening can help during challenging times. She is grateful to her garden, as well as to her fellow Willow Valley Communities gardeners, for helping her during the difficult time of her husbands unexpected passing. Gardeners, and she doesnt know exactly who, would come and help by doing extra work around her plot. Residents just came in and helped, Angela says. Weeding, cutting, trimming, harvesting whatever work needed to be done. Thats the way Residents are here at Willow Valley Communities: very supportive. Resident Keith Yoder, who coordinates the Spring Run Garden, is not at all surprised by the variety of gardeners at Willow Valley Communities or by the reasons they enjoy the activity so much. He agrees that gardening is definitely a hobby that enhances well-being. Though hes known this himself for years, he refers to an article put out by CNBC that states how gardening can add years to your life. And life to your years, Keith adds. Gardening gets you into nature. Its good exercise for your body and your mind plus, you get to eat what you grow!
Pampering for Self-care & Wellness
The Willow Valley Communities Day Spa is a destination for wellness and renewal. Its a critical component of the comprehensive Mind, Body, Spirit approach to wellness of Willow Valley Communities. The Day Spa offers many ways to soothe, calm, invigorate, or rejuvenate. A full range of professional services, all performed by our attentive and inviting staff, allows Residents to create their own regimen for personal well-being and beauty. These services include manicures and pedicures, skin care, facials, revitalizing peels, waxing, tanning, microdermabrasion, and body treatments with a wide range of different massage modalities, wraps, and scrubs. The Relaxation Room, with its beautiful waterfall and Himalayan Salt Wall, is a main feature of The Day Spa. It provides a peaceful and well-appointed environment in which to relax and offers a perfect and welcome respite between services. Himalayan salt rich in negative ions and essential nutrients and minerals offers numerous health benefits for our bodies, such as stress reduction, energy increases, and mood boosts at a biochemical level. Day Spa Manager Diamando Wallace says, Self-care is essential. Although manicures and pedicures are a well-deserved treat, they offer so much more to Residents sense of well-being. You can see the boost in a clients self-confidence as they walk out feeling refreshed. Massages are one of the most popular services requested by Residents, and The Day Spa offers a wide menu of options, including hot stone and aromatherapy. Emily Ransing, Willow Valley Communities Day Spa Massage Therapist, says, Massage is meant to enhance your well-being physically and mentally. I frequently remind my clients that this is their time to focus on themselves to feel healthier. I do all I can to send each client home feeling better than when they arrived. A Willow Valley Communities Resident was asked about her massage as she was leaving The Day Spa one afternoon. She said, After a massage with Emily, your body is so relaxed that you can focus on the things that you often overlook the air is sweeter, the birds are more melodious, the day is brighter. You are better equipped to face the next days, whatever they may bring. As she walked out of the Cultural Center to her car, she added with a smile, Its also a way to take the tension out of your body although theres not much tension at Willow Valley Communities!
Now is a Great Time to Explore Willow Valley Communities
Willow Valley Communities Manager of Sales, Margie Seagers, has been pleasantly surprised by the recent increased interest shes received from prospects wanting to learn more about life in our communities. As 2020 came to a close, she found many seniors in a reflective mood, examining where they had been, where they are now, as well as where and how they want to spend the next phase of their lives. Ive been hearing from seniors that they want the increased support from a community they can trust, Margie said. She added that the people shes been hearing from have been doing a good job at staying safe in their own homes, but over time its gotten pretty lonely. Its also been difficult to have consistent services on their own during the pandemic. As much as people say they can depend on their adult children or close friends to help them, there does come a time when that person is unable to help because of their own family obligations. Margie has also found that Willow Valley Communities 35-plus years reputation of excellence in senior living means even more now to seniors especially Baby Boomers. She said that Lifecare, Willow Valley Communities financially smart contract that promises supportive care, if ever needed, without an increase to monthly service fees, especially has caught their attention. Baby Boomers traditionally want to feel empowered to make their own decisions, and theyve spent their time researching. They desire a secure community environment, but they want the facts, and Willow Valley Communities has several ways to tell them more about what senior living options are available to them. We are happy to have that conversation, in person or online, to give them all the information they need to make a decision that is right for them, she said. Margie said shes had many visitors who have come to Willow Valley Communities during the COVID-19 pandemic for a safe, socially distant, in-person informational meeting. The process is very easy, she explained. Everyone goes through our screening process at the Cultural Center just two minutes away from the Welcome Center, where we then can meet. The Welcome Center has specially adapted, socially distant and private meeting areas. Prospects can comfortably meet with a Sales Counselor and get all the information they need about becoming a Resident at Willow Valley Communities. Tours are available for those interested in seeing more. For those who prefer a virtual meeting from the comfort of their own home, that is also easy to arrange. Willow Valley Communities Sales Counselors are happy to arrange an online Zoom meeting at a prospects convenience. And its as detailed as an in-person meeting, Margie noted. Willow Valley Communities Sales Counselors are known for their thorough knowledge of senior living and are able to explain all options thoroughly during an online meeting. She also said that, if needed, Sales Counselors can show close-up features of a specific residence, virtually, to a prospective Resident. Plus, virtual tours of Willow Valley Communities campus are always available online at WillowValleyCommunities.org. Its almost like being right here! Margie quipped. If youre considering a move to a secure senior living community, Willow Valley Communities is ready to provide all the information you need, whenever and however you wish. Whether its in person, online by appointment, or through WillowValleyCommunities.org, Willow Valley Communities is available to help you imagine your Life Lived Forward.
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Aqualane Clinical Research
Memory & Dementia Care 3200 Bailey Lane, Naples, Florida, 34105HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. Striving to make clinical trials a practical healthcare option, we provide a comfortable, caring and compassionate environment.Our founders are passionate about their contributions to the advancement of medicine and to the opportunities they provide to people searching for new treatment options. With expertise and experience in research and the central nervous system, you can trust our team of neurologists and researchers to provide the best possible opportunity for you or your loved one.OurTeamDr. William A. Justiz, MDMedical Director, Principal InvestigatorDr. William Justiz completed his undergraduate degree at Northwestern University before receiving his medical degree from the University of Miami School of Medicine. He is board certified in neurology and is a certified physician investigator through the Association of Clinical Research Professionals.With over 20 years of research experience and specialization in degenerative diseases of the nervous system, he has been in continuous practice in Naples, Florida since 1999. He is a founding member of the clinical research program that has grown into Aqualane Clinical Research.Community outreach and service is one of the core values of Dr. Justiz and Aqualane Clinical Research. Dr. Justiz demonstrates this with his 23-year commitment to providing low-cost or free services to epilepsy patients through Epilepsy Services of Southwest Florida. In addition, he has delivered a free educational lecture series every month on all Alzheimer's topics since 2015 through the Alzheimer's Support network.Kelly E. Calistri, B.A.Chief Operating Officer, Site DirectorKelly is a native Floridian, born and raised in Central Florida. Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDPrincipal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. He enjoys teaching colleagues, medical residents and patients on such topics as Multiple Sclerosis and Myasthenia Gravis. In his spare time, he loves riding roller coasters with this family and playing with his two dogs.Micaela M. Acres, RN, BSNInfusion NurseJacqueline E. BradyCommunity Outreach Coordinator/ ReceptionMatthew B. Cagney, B.S.Clinical Research CoordinatorElena Capron, B.S.Regulatory Coordinator / Social Media CoordinatorBrittany N. Cordero, B.S.Office Manager / Human ResourcesJessica M. DEntremont, RN, MPH, BSNInfusion NurseDarious T. Davis, M.A.Head of Business DevelopmentLaura Gold, B.S.Finance CoordinatorKarma L. Hamilton, M.S.Lead RaterBethany J.M. Henchesmoore, MBAClinical Research CoordinatorJennifer Jimenez-Perez, RN, BSNInfusion NurseCarmen L. Ojeda, M.S.Quality Assurance / Quality ControlMichelle A. O'Neill, M.S.RaterMayve SantosResearch PharmacistAlexandria L. SmithClinical Research Coordinator
Aqualane Clinical Research
Dementia Care 3200 Bailey Lane, Naples, Florida, 34105HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. Striving to make clinical trials a practical healthcare option, we provide a comfortable, caring and compassionate environment.Our founders are passionate about their contributions to the advancement of medicine and to the opportunities they provide to people searching for new treatment options. With expertise and experience in research and the central nervous system, you can trust our team of neurologists and researchers to provide the best possible opportunity for you or your loved one.OurTeamDr. William A. Justiz, MDMedical Director, Principal InvestigatorDr. William Justiz completed his undergraduate degree at Northwestern University before receiving his medical degree from the University of Miami School of Medicine. He is board certified in neurology and is a certified physician investigator through the Association of Clinical Research Professionals.With over 20 years of research experience and specialization in degenerative diseases of the nervous system, he has been in continuous practice in Naples, Florida since 1999. He is a founding member of the clinical research program that has grown into Aqualane Clinical Research.Community outreach and service is one of the core values of Dr. Justiz and Aqualane Clinical Research. Dr. Justiz demonstrates this with his 23-year commitment to providing low-cost or free services to epilepsy patients through Epilepsy Services of Southwest Florida. In addition, he has delivered a free educational lecture series every month on all Alzheimer's topics since 2015 through the Alzheimer's Support network.Kelly E. Calistri, B.A.Chief Operating Officer, Site DirectorKelly is a native Floridian, born and raised in Central Florida. Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDPrincipal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. He enjoys teaching colleagues, medical residents and patients on such topics as Multiple Sclerosis and Myasthenia Gravis. In his spare time, he loves riding roller coasters with this family and playing with his two dogs.Micaela M. Acres, RN, BSNInfusion NurseJacqueline E. BradyCommunity Outreach Coordinator/ ReceptionMatthew B. Cagney, B.S.Clinical Research CoordinatorElena Capron, B.S.Regulatory Coordinator / Social Media CoordinatorBrittany N. Cordero, B.S.Office Manager / Human ResourcesJessica M. DEntremont, RN, MPH, BSNInfusion NurseDarious T. Davis, M.A.Head of Business DevelopmentLaura Gold, B.S.Finance CoordinatorKarma L. Hamilton, M.S.Lead RaterBethany J.M. Henchesmoore, MBAClinical Research CoordinatorJennifer Jimenez-Perez, RN, BSNInfusion NurseCarmen L. Ojeda, M.S.Quality Assurance / Quality ControlMichelle A. O'Neill, M.S.RaterMayve SantosResearch PharmacistAlexandria L. SmithClinical Research Coordinator
Aqualane Clinical Research
Clinical Studies 3200 Bailey Lane, Naples, Florida, 34105About UsWith over 55 years of clinical research experience, Aqualane Clinical Research is committed to advancing medical science and improving lives. By leveraging our expertise in research, we dedicate ourselves to the community and the pursuit of innovative solutions for complex health challenges through the study of new medications.Our MissionWe strive to serve our community by providing cutting-edge experimental treatments for difficult-to-control and untreated neurological conditions. Through ethical, patient-centered research, we seek to develop breakthrough therapies that address unmet medical needs.What We DoAqualane Clinical Research is a leading clinical research organization specializing in the development of new treatments for a wide range of neurological and neuropsychiatric disorders. We collaborate closely with patients, caregivers, and industry sponsors to ensure the safe, ethical, and effective study of emerging therapies. Our goal is to offer hope and innovation where current treatments are limited or nonexistent.Our Commitment to Excellence50+ Years of Expertise Our experienced team of doctors and research professionals is dedicated to providing the highest level of care.100% Patient Satisfaction We are committed to guiding patients through the clinical trial process with compassion and transparency.Our Clinical Research AreasWe are actively conducting research in the following areas:Alzheimers Disease Investigating potential treatments to slow, halt, or reverse disease progression.Parkinsons Disease Developing therapies to improve quality of life and manage symptoms.Essential Tremor Exploring the genetic factors and treatment options for this movement disorder.Multiple Sclerosis Advancing treatments through biomarker analysis and cutting-edge imaging.Migraine Studying new medications to provide relief for those suffering from chronic migraine attacks.Neuropsychiatric Conditions Researching novel therapies for depression, anxiety, and psychiatric symptoms associated with neurological disorders.Get InvolvedDiscover how you can participate in a clinical study and contribute to the future of medical innovation. Our team is ready to answer any questions you may have.Meet the TeamDr. William A. Justiz, MDMedical Director, Principal InvestigatorDr. William Justiz completed his undergraduate degree at Northwestern University before receiving his medical degree from the University of Miami School of Medicine. He is board certified in neurology and is a certified physician investigator through the Association of Clinical Research Professionals.With over 20 years of research experience and specialization in degenerative diseases of the nervous system, he has been in continuous practice in Naples, Florida since 1999. He is a founding member of the clinical research program that has grown into Aqualane Clinical Research.Community outreach and service is one of the core values of Dr. Justiz and Aqualane Clinical Research. Dr. Justiz demonstrates this with his 23-year commitment to providing low-cost or free services to epilepsy patients through Epilepsy Services of Southwest Florida. In addition, he has delivered a free educational lecture series every month on all Alzheimer's topics since 2015 through the Alzheimer's Support network.Kelly E. Calistri, B.A.Chief Executive Officer, Site DirectorKelly is a native Floridian, born and raised in Central Florida. Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDMedical Advisor, Principal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. He enjoys teaching colleagues, medical residents and patients on such topics as Multiple Sclerosis and Myasthenia Gravis. In his spare time, he loves riding roller coasters with this family and playing with his two dogs.