Lungs And Age: How Time Impacts The Respiratory System

As we grow older, our needs and priorities evolve, often making our living spaces feel less suitable than they once were. For seniors, the comfort of home becomes even more essential, yet the task of organizing and maintaining a home can become overwhelming. At A Call to Order Professional Organizers, we understand the emotional and physical challenges that seniors face. Our mission is to provide compassionate, expert assistance to help seniors feel at home, wherever they choose to live. Through our personalized services, we strive to create spaces that are not only organized but also nurturing and comfortable.Understanding Seniors' Needs1. Emotional Attachment to BelongingsFor many seniors, their homes are filled with a lifetime of memories and cherished belongings. Each item tells a story and holds sentimental value. The thought of sorting through these possessions can be daunting and emotionally taxing.Tips for Respectful Decluttering:Listen with Empathy: Take the time to listen to the stories behind the items. This shows respect for their memories and makes the process less about discarding and more about cherishing.Gentle Guidance: Encourage seniors to keep items that bring joy and consider donating or gifting those that don't. Highlight the positive impact of giving items a new life.Memory Preservation: Offer creative solutions to preserve memories, such as creating photo albums or digital archives of beloved items that can't be kept.2. Safety and AccessibilityAs mobility becomes a concern, its crucial to ensure that a seniors living space is safe and easily accessible. Organizing with a focus on safety can prevent accidents and make daily tasks more manageable.Strategies for a Safe Home:Clear Pathways: Ensure that hallways and living areas are free from clutter to reduce the risk of falls.Accessible Storage: Place frequently used items within easy reach to minimize the need for bending or stretching.Adaptive Solutions: Incorporate adaptive equipment and furniture arrangements that cater to mobility issues, such as grab bars in the bathroom and stable seating options.Creating a Sense of Home1. Personalized SpacesA home should reflect the personality and preferences of its inhabitants. For seniors, maintaining a sense of identity through their living environment is vital for emotional well-being.Personalization Tips:Favorite Items: Make sure that favorite belongings, like a beloved armchair or treasured photographs, are prominently displayed and easily accessible.Comfort Zones: Create cozy areas where seniors can relax, read, or engage in hobbies. A well-placed chair by a window, a dedicated crafting table, or a garden nook can enhance their quality of life.Warm Aesthetics: Use colors, textures, and decorations that evoke warmth and comfort. Familiar and favorite colors can make a space feel more inviting and homely.2. Encouraging IndependenceHelping seniors maintain their independence is crucial for their self-esteem and happiness. An organized home can empower them to perform daily tasks more efficiently and confidently.Empowering Through Organization:Logical Layouts: Arrange items in a logical order that matches their routines. For example, keep kitchen utensils near the stove and daily medications by the bedside.Simplify Systems: Implement simple organizational systems that are easy to maintain. Clear labels, color-coded bins, and straightforward filing systems can reduce confusion and make upkeep manageable.Regular Check-ins: Offer ongoing support to adjust the organization as needs change. Regular visits can help keep the home functional and address any new challenges that arise.At A Call to Order Professional Organizers, our commitment goes beyond mere organization. We aim to create environments where seniors feel safe, comfortable, and truly at home. By understanding their unique needs and providing compassionate, personalized support, we help transform living spaces into nurturing havens. Our approach ensures that every senior we assist not only enjoys an organized home but also experiences an enhanced quality of life filled with joy, dignity, and independence. If you or a loved one is facing the challenges of aging in place, we are here to help you feel at home, every step of the way.

Caring Communication: Keeping Families Connected During MovesMoving is often considered one of life's most stressful events, and this stress can be magnified for families, especially when seniors are involved. At A Call to Order Professional Organizers, we understand that a move isn't just about transporting belongings from one place to another; it's about ensuring that the emotional bonds within a family remain strong and intact. Our goal is to facilitate a smooth transition while prioritizing compassionate communication to keep families connected and supported throughout the process.The Importance of Communication During a MoveEffective communication is the foundation of any successful move. It helps manage expectations, reduces anxiety, and ensures that everyone involved feels heard and respected. Here are some key aspects of communication that can make a significant difference:1. Open and Honest ConversationsFrom the moment the decision to move is made, it's essential to have open and honest conversations with all family members. For seniors, the thought of leaving a home filled with memories can be overwhelming. Taking the time to listen to their concerns and feelings can provide much-needed reassurance and comfort.Tips for Open Communication:Schedule Family Meetings: Regular family meetings can create a safe space for everyone to express their thoughts and feelings. These meetings should be inclusive, ensuring that each family member, especially seniors, has a chance to voice their concerns and preferences.Active Listening: Practice active listening by acknowledging feelings and validating concerns. This can help build trust and understanding within the family.Transparency: Be transparent about the reasons for the move, the timeline, and what to expect. Clear information can help reduce uncertainty and stress.2. Including Seniors in Decision-MakingEmpowering seniors to be part of the decision-making process can significantly reduce their anxiety and resistance to change. When seniors feel included and valued, they are more likely to embrace the transition positively.Strategies for Inclusion:Respect Preferences: Take into account seniors' preferences regarding what items to keep, donate, or discard. Their input is invaluable in making the new space feel like home.Tour the New Home Together: If possible, visit the new home together before the move. Familiarizing seniors with the new environment can help ease their transition.Plan Together: Involve seniors in planning the layout and organization of their new space. This not only ensures that their needs are met but also gives them a sense of ownership and control.Supporting Emotional Well-Being During the MoveMoving is not just a physical process; it's an emotional journey. Supporting the emotional well-being of all family members, especially seniors, is crucial for a successful transition.1. Creating a Supportive EnvironmentCreating a supportive environment where emotions can be expressed freely helps in coping with the stress of moving. Providing emotional support can make the transition smoother and more positive.Ways to Provide Emotional Support:Acknowledge Emotions: Recognize that feelings of sadness, anxiety, and nostalgia are natural during a move. Encourage open discussions about these emotions.Seek Professional Help: If the emotional burden becomes too heavy, consider seeking the help of a therapist or counselor. Professional guidance can provide coping strategies and emotional relief.Celebrate Memories: Find ways to celebrate the memories associated with the old home. Creating a memory book or organizing a farewell gathering can help in honoring the past while looking forward to the future.2. Staying ConnectedMaintaining family connections during the move is essential for emotional support and continuity. Staying connected helps in reassuring seniors that they are not alone and that their family is with them every step of the way.Ways to Stay Connected:Regular Check-ins: Regular phone calls, video chats, or in-person visits can provide much-needed emotional support. Ensure that seniors know they are always just a call away.Involve the Whole Family: Encourage family members, including grandchildren, to participate in the moving process. This can create a sense of unity and shared purpose.Share Updates: Keep everyone informed about the progress of the move. Sharing updates can help in managing expectations and reducing anxiety.At A Call to Order Professional Organizers, we believe that the heart of a successful move lies in compassionate communication and emotional support. By fostering open conversations, including seniors in decision-making, and providing a supportive environment, we help families navigate the complexities of moving with grace and unity. Our commitment is to ensure that every move is not just a change of address but a journey towards a new, loving, and organized home. With care and compassion, we strive to keep families connected and supported throughout the moving process.

Recently, we have talked about what Alzheimers is, different types of Alzheimers Disease & what causes Alzheimers Disease. After laying that groundwork we can finally discuss and review new medications and treatment solutions for Alzheimers.We will start this series of blogs reviewing Leqembi (lecanemab).  As in the last blog, I will remind you, I am not a doctor.  I am not a medical professional.  I am a person who can take detailed medical information, research it, and create content & imagery that will make it easier for you to understand a specific concept.  You should NEVER use my content to make medical decisions for yourself or your loved one. However, you can take the content I provide to begin conversations with your doctor.   What is Leqembi?  Leqembi is a medication that is used to treat early-stage Alzheimer's Disease. It is an FDA-approved treatment that targets one aspect of the underlying biology of the disease. Leqembi works by reducing the amount of amyloid-beta proteins in the brain, which are a key factor in Alzheimer's DiseaseLeqembi is administered as an intravenous (IV) infusion every two weeks at an infusion center. Each infusion usually lasts about an hour. Leqembi is approved for people with mild Alzheimer's disease, which means they have some memory and thinking problems, but their symptoms are not severe. It can also be used to treat mild cognitive impairment (MCI) and mild dementia due to Alzheimer's disease. It is important to note that Leqembi is not a cure. I will repeat it to be clear.  Leqembi is NOT a cure for Alzheimers Disease. Alzheimers Disease is triggered by multiple conditions such as diabetes, genetics, toxic environmental exposure, and inflammation. Leqembi was designed to slow Alzheimer's progression by identifying and attacking beta-amyloid proteins in the brain.  This is significant because beta amyloids are one of the hallmarks of Alzheimers. These proteins clump together to form plaques that destroy neurons. Neurons are the cells that form the brains communication system. Leqembi is a monoclonal antibody that binds to these plaques and breaks them apart.What is a monoclonal antibody?Monoclonal antibodies (mAbs) are laboratory-made proteins that are a type of targeted therapy used to treat a variety of diseases, including some types of cancer and COVID-19. Monoclonal antibodies are highly specific because they are derived from a single clone of cells and are engineered to closely reflect the structure of naturally produced human proteins. This means that the body handles them similarly. The body does not metabolize monoclonal antibodies like it would a synthetic medication.   mAbs are created in a lab from living sources that produce antibodies, such as human B cells.  Or immunized animals. The first step in the process is to express a purified antigen, which is often a critical step. The mAbs are then produced by identical clones of B lymphocytes against a specific antigen.How are monoclonal antibodies produced? The traditional monoclonal antibody production process usually starts with a generation of mAb-producing cells (i.e. hybridomas) by fusing myeloma cells with desired antibody-producing splenocytes (e.g. B cells). These B cells are typically sourced from humans or animals, usually rodents.Human mAbs can be used to target and neutralize specific proteins that induce an immune response, such as those associated with inflammation in psoriasis and other autoimmune disorders. Leqembi is an example of a human mAb used to treat Alzheimer's disease.Advantages of using mAbs:        Precision - mAbs are more precise than other treatments, which can improve effectiveness and reduce side effects. For example, monoclonal antibody therapy can target cancer without damaging healthy cells.       Safety - mAbs are safer and less toxic than chemotherapy drugs, which can improve patient survival and well-being.       Quality - mAbs quality is consistent across production batches, which is important for both therapy and diagnostics.       Quantity - mAbs can be produced in large quantities.       Other advantages - mAbs also have fewer off-target adverse effects, fewer drug-drug interactions, and higher specificity.Disadvantages of mAbs in an overview long lead times for traditional mAbs manufacture methods (hybridoma) relatively high cost of goods laborious process, hybridoma cell generation has low yields selectivity is hard to achieve for peptide targets with few amino acid residues contamination and risk of loss for hybridoma cultures limited uses due to the mode of action It is not uncommon to have an infusion reaction when taking mAbs.  It is like an allergic reaction. Symptoms can include fever, chills, weakness, headache, nausea, vomiting, diarrhea, low blood pressure, and rashes, and are more common when the drug is first given. This is your bodys response to taking a biological medication and will usually subside as you get used to it.Who can take Leqembi?Now that we understand what Leqembi is and how it works.  Who can take Leqembi?In theory, anyone experiencing mild cognitive impairment or the early stages of Alzheimers Disease.  However, to qualify for treatment with Leqembi, patients must meet the same criteria used in the clinical trials that led to its approval:       Be between the ages of 50 and 90       Have a confirmed presence of beta-amyloid plaques in the brain        Have mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease       Have a body mass index (BMI) between 17 and 35Potential patients must undergo diagnostic testing to confirm the presence of beta-amyloids before starting treatment, which is usually done with a PET scan and/or a spinal tap. Leqembi has not been tested on people with more advanced Alzheimer's or those without symptoms, so they do not qualify for treatment. Side Effects of LeqembiThere are potential side effects with every medication.  No one should be surprised that there are side effects with Leqembi.  The following information was taken word for word from Eisai and Biogen, the manufacturers and distributors of Leqembi:LEQEMBI can cause serious side effects, including:       ARIA (amyloid-related imaging abnormalities). There are usually no signs of ARIA. In rare cases, it can lead to serious complications       ARIA can show up as swelling in parts of the brain or small spots of bleeding       Larger areas of bleeding in the brain may occur, but this is uncommon       ARIA usually goes away over time       Most people with ARIA dont have any symptoms. However, some people may notice:headacheconfusion that gets worsedizzinessvision problemsnauseaproblems walkingseizures      Some people have a gene called ApoE4 that may increase the risk of ARIA. Talk to your healthcare provider about testing to see if you have this gene      Some medicines can increase the risk of larger areas of bleeding in the brain for people taking LEQEMBI. Talk to your healthcare provider to see if any of the medicines youre taking increase this risk      Your healthcare provider will check for ARIA with MRI (magnetic resonance imaging) scans before you start LEQEMBI and during treatmentI want to be careful to not over-dramatize these side effects.  As I have said in previous Blogs, I am a study buddy for a loved one participating in a research program with (BAN2401) Leqembi.  My loved one has experienced Aria-E and Aria-H.  The Aria-H experience was by far the most dramatic of the two.  It started when my loved one woke up from a deep sleep after feeling and hearing what she described as an explosion in her brain.  She said it felt like she had been hit by a brick.  She sat up and placed her hand on top of her head as you would when something just hit you.  When she removed her hand to look at it, she fully expected to see blood on her hand.  But there was no blood. She got up out of bed, went to the bathroom, made a note in her journal, laid back down, and went back to sleep.  There are some important things to point out here:She said she felt like she was hit with a brick.  However, there are no pain receptors in the brain. And later she would say that it felt like being hit by a brick but without pain.  I say this to be clear that as traumatizing as it was, there was no pain.She calls it an explosion in her head.  She is confident that she heard the sudden micro hemorrhage take place.  And that she heard the blood flow.  I am 100% confident that she did.  My loved one is not one to over-dramatize facts.But how big was this hemorrhage?  To be classified as a micro hemorrhage it must be smaller than 5 millimeters in diameter.  How big is that?  The size of her micro hemorrhage was between the size of the tip of a pencil lead and half the diameter of the eraser tip.  VERY small.  Despite the potential of brain swelling and another brain bleed, I stand behind her choice to continue to take Leqembi.  Knowing that any day, I might get a phone call with her telling me it happened again.  Because without this medication, I believe her cognitive decline will become significant.  We are not giving up on her and her desire to be a volunteer for Alzheimers research.How do I get started?OK, so you heard all about the scary potential of experiencing a brain bleed and potential brain swelling.  You understand that by taking no action, you are guaranteeing continued cognitive decline.  And you want to start the evaluation process to see if you are a good candidate for Leqembi treatment.  How do you get started?  There are 2 options:Schedule an appointment with your neurologist to learn more. If you do not have a neurologist or if you want to be sure you are working with a Leqembi-friendly neurologist, send me an email (teri@protonmail.com).  I will need to know where you are located.  With that information, I will get back to you with a couple of options. This is a great option if you have insurance that will pay for all or part of the testing and medication. Schedule an appointment with an Alzheimers Research facility.  Research doctors have the same qualifications as neurologists in private practice.   However, most research studies do not guarantee that you will receive the medication in the first round.  You may receive a placebo first and the study medication later. Research studies often offer protocols that are not available to the public yet. If you do not have insurance, this is a great solution to get the medication you need to slow cognitive decline. Research studies offer protocols at no charge.  You will pay nothing. How much does it cost?The answer to that question is difficult to answer because there are so many factors to be considered. The Japanese drugmaker Eisai set the list price for Leqembi, at $26,500 per year in the United States. However, the actual cost for patients will vary depending on their insurance coverage. For example, Medicare beneficiaries are responsible for 20% of the cost after meeting their Part B deductible, which means the out-of-pocket cost for Medicare enrollees is $5,300 per year. Other factors that may affect the cost include Medicare supplemental or other secondary insurance, Medicare Advantage plans, and Medicaid. In addition to the cost of the drug itself, there are also associated expenses for diagnosing and monitoring patients, such as PET scans, MRI scans, and clinical visits.  Is it worth it?It is for my loved one.  Despite experiencing brain swelling and a brain bleed, she wont stop as long as it is available.I know that if I am diagnosed with mild cognitive impairment or Alzheimers disease, I would take it or a similar mAB as a multi-step treatment protocol.  I would work with an Alzheimers Disease researcher to be sure every bit of information is captured. Is it worth it to you?  Only you can decide.