PD Associated Risk Factors in Western PA

Posted on

May 14, 2018

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Western Pennsylvania is like the perfect storm in terms of risk factors for developing Parkinsons disease. There are three primary risk factors that have been associated with PD:
1.
Age (older persons at a higher risk)
2.
Genetic Factors (mutations on certain genes which are common in two particular ethnic backgrounds may account for as many as 15%-20% of the cases of Parkinsons disease, 1.5 2 times greater than in other populations)
3.
Environmental factors that are associated with agriculture and industry (particularly in the midwest northeast regions) have been associated with a higher risk.

Age is considered the primary risk factor in idiopathic PD. The prevalence rate in US residents over the age of 65 approximately 1.6%. This rate goes up to about 3% for people over the age of 80 and continues to increase with age without signs of plateau. Allegheny County has one of the oldest populations per capita in the US. As the demographics continue to shift to a more senior population, the number of people diagnosed with PD will grow accordingly.

The genetic indicator most commonly associated with PD is LRRK2. It is thought to be the cause in about 2% of the total cases of PD. However, this mutation is 10 time more prevalent in Ashkenazi Jews than in the general population and it is believed to increase their risk factor accordingly. Ashkenazi Jews are at a 6 10 times higher risk of developing PD as a result. Allegheny County (Pittsburgh) has a significant Jewish community.
There are an increasing number of environmental toxins which contribute to developing the disease such as chemicals used as herbicides and pesticides in agriculture and certain heavy metals (pollutants) that are associated with industrial manufacturing. Although our region is less dependent on agriculture and industry now, steel and farming were a big force in the regions economy as recently as 40 50 years ago.
Luckily, the region has the Parkinson Foundation Western Pennsylvania as a resource. The Foundation serves primarily people living in Pittsburgh and many surrounding communities. The Parkinson Foundation Western Pennsylvania was formed by volunteers in 1995 with the purpose of supporting research efforts to find a cure and provide support for those with PD and their families

Editors Note: This article was submitted by David Von Hofen, Director of Programs and Outreach, Parkinson Foundation Western Pennsylvania. If you would like more information about PD and the Foundation, please call 412.837.2542 or visit pfwpa.org.

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