The Success of Aducanumab in Treating Alzheimer's Disease
Aducanumab is a medication that has received a lot of attention in recent years for its potential in treating Alzheimer's disease. Alzheimer's is a progressive neurological disorder that affects memory, thinking, and behavior, and there is currently no cure for the condition. Aducanumab is a type of drug called a monoclonal antibody, which works by targeting and removing sticky deposits of a protein called beta-amyloid that build up in the brains of individuals with Alzheimer's.
Aducanumab has shown promising results in treating Alzheimer's disease. It is a monoclonal antibody that targets beta-amyloid, a protein that accumulates in the brain and is associated with the development of Alzheimer's. The drug works by removing beta-amyloid from the brain, slowing the progression of the disease and potentially improving cognitive function.
In clinical trials, Aducanumab has been shown to reduce beta-amyloid levels in the brain and slow cognitive decline in patients with early Alzheimer's disease. The results of these trials have been highly promising and have led to the approval of Aducanumab by regulatory agencies in several countries.
One of the most significant findings of the clinical trials was the observation of a statistically significant reduction in clinical decline in patients who received Aducanumab. This reduction in decline was observed in measures of cognitive function, such as memory and thinking skills, as well as in measures of daily functioning, such as the ability to perform basic activities of daily living.
Another important finding from the trials was the observation of a favorable safety profile for Aducanumab. The majority of patients who received the medication did not experience significant side effects, and those that did were generally mild and manageable.
In November 2021, the United States Food and Drug Administration (FDA) granted accelerated approval for Aducanumab as a treatment for Alzheimer's disease. This decision was based on evidence from clinical trials, as well as on the need for new treatments for Alzheimer's, which is a growing global health crisis. The FDA has required the manufacturer of Aducanumab, Biogen, to conduct additional studies to confirm the drug's benefits and to better understand its risks and side effects.
The development of Aducanumab has been the subject of numerous clinical trials, with positive results seen in early trials in reducing beta-amyloid deposits in the brains of individuals with Alzheimer's. It is important to note however, that more recent trials have produced mixed results, with some studies showing a slowing of cognitive decline in individuals taking Aducanumab and others showing little to no effect.
Aducanumab is a promising new treatment option for Alzheimer's, although more research is needed to determine its long-term safety and effectiveness. Individuals and their families should discuss with their healthcare provider the potential benefits and risks of taking Aducanumab, as well as other treatment options that may be available.
In conclusion, Aducanumab is a medication that has received attention for its potential in treating Alzheimer's disease. The drug works by targeting and removing beta-amyloid deposits in the brain, which is believed to contribute to the progression of the disease. While the results of clinical trials have been mixed, the FDA has granted accelerated approval for Aducanumab as a treatment for Alzheimer's, with additional studies required to confirm its benefits and risks. Individuals and their families should consult with their healthcare provider to determine if Aducanumab is the right treatment option for them.
References:
· Alzheimer's Association. (2021). Aducanumab.
· Biogen. (2021). Aducanumab.
· FDA. (2021). Aducanumab Approval Letter.
· National Institute on Aging. (2021). Alzheimer's Disease and Dementia.
Author: Kathleen Warshawsky, BSN, RN | Publisher Seniors Blue Book Greater Dallas | https://www.linkedin.com/in/kathleenwbsnrn/
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By Faith Protsman, MD, Regional Medical Director, VITAS HealthcareTwo recent studies highlight how sepsis impact often extends well beyond the acute event that led to a patients hospitalization. The studies emphasize two particular points that should inform physicians and clinicians as they consider referring these patients to specialized care: Medicare patient data gathered between 2012-2017 shows that sepsis patients face considerably poorer health outcomes following hospital discharge when compared to non-sepsis patients, including elevated risk for death and increased use of advanced healthcare services. Sepsis survivors exhibit strong indicators of persistent inflammation and immunosuppression for up to a year after hospital discharge, increasing their risk of readmission or death. Both studies indicate a significantly elevated risk of death among sepsis patients after they have been discharged and ostensibly cured. Of course, sepsis patientsparticularly those of the Medicare cohort, who are largely of advanced agerarely leave the hospital in better condition than they entered.The Yende study, in particular, shows that neuroendocrine and inflammatory responses to sepsis can continue long after the patient survives a septic episode. For patients with advanced or chronic diseasesas was the case with nearly 78% of participants in the studythese biomarkers are associated with decline.Post-sepsis Discharge: A Critical JunctureIn many cases, these individuals life expectancies upon discharge will be less than six months. This is a critical juncture: While comfort-focused hospice care could provide an ideal source of support for the eligible patient, their family, and their caregiver(s), most sepsis patients are simply sent home without even a discussion about palliative end-of-life care and its benefits.Frankly, such an oversight is a disservice to everyone involved. The sepsis patient is left with physical and/or cognitive dysfunction, often without significant options for symptom management. Their partner or family will either need to assume caregiving duties or turn to costly private services. And the physician and hospital staff will likely see the patient again following another acute event, a readmission that impacts performance scores, strains resources, and unnecessarily fills beds.By no means do I intend to lay the blame for these unfortunate circumstances on physicians. Timely hospice referrals require ongoing education about end-of-life care, and open, ongoing communication between hospice providers and referral sources.More Help: How to Talk About Hospice Care >Those of us in hospice are working hard to bridge the gap, but even as our healthcare system transitions to a value-based model, the mentality of fee-for-service still permeates our nations acute-care facilities, and many hospitalists see a discharge home as a success.Hospice: A New Way Of Judging SuccessIn hospice, we judge our successes on the patients quality of life and the fulfillment of their goals and wishes near lifes end. Usually, that means going home with 24/7 support from an interdisciplinary hospice team. Whether home is a traditional residence, an assisted living facility, or nursing home, the hospice team will assist caregivers (and/or facility staff) with direct clinical care and education, integrative services, bereavement support, and delivery of medication, equipment, and supplies.In other cases, improving quality of life means remaining in a general inpatient setting with hospice support, taking the burden off hospital staff until the patient is able to transition home or until the patient dies. Hospice offers complex modalities in any setting, so patients who would otherwise be confined to an ICU can usually return home to be among loved ones.With support from hospice, a sepsis patient and their family are more likely to report higher satisfaction of care and greater quality of life. The patients emotional and spiritual needs can be met alongside their physical needs, thanks to care from chaplains, social workers, music and massage therapists, and other integrative specialists. Finally, the patient is more likely to die at home, surrounded by loved ones, rather than in the hospital.Because sepsis is most common in patients with advanced or chronic diseases that indicate hospice eligibility, acute incidences of sepsis should always trigger a hospice eligibility assessment. We owe it to our patients, their loved ones, and our colleagues in healthcare, all of whom can benefit from the support that timely end-of-life care offers.
The Waxahachie High School Alumni Association, also known as the Waxahachie Ex-Students' Association, has long been a pillar of support for its graduates. Established in 1961, the association has grown to become a vital resource for alumni, providing a range of services and opportunities to stay connected with their alma mater and fellow graduates.One of the standout features of the Waxahachie High School Alumni Association is its commitment to providing valuable resources to its members. Among these resources is the Seniors Blue Book, a comprehensive guide that offers information on senior living options, healthcare services, and other essential resources for seniors. This guide is an invaluable tool for alumni who are navigating the complexities of aging and seeking reliable information to make informed decisions about their future.In addition to the Seniors Blue Book, the alumni association offers a variety of other resources and services. These include: Scholarship Programs: The association awards numerous scholarships to graduating seniors each year, helping to ease the financial burden of higher education and support the next generation of Waxahachie graduates. Reunion Planning: The association assists alumni in organizing class reunions, providing a platform for classmates to reconnect and reminisce about their high school days. Community Events: The association hosts various events throughout the year, including homecoming celebrations, community-building activities, and volunteer opportunities. Networking Opportunities: Alumni can take advantage of networking events and online platforms to connect with fellow graduates, share career advice, and explore professional opportunities. The Waxahachie High School Alumni Association's dedication to supporting its members is evident in the wide range of resources and services it offers. By providing tools like the Seniors Blue Book and fostering a strong sense of community, the association ensures that Waxahachie graduates remain connected and supported throughout their lives. Click Here for more information about the Waxahachie High School Alumni Associationand the resources it provides.
Understanding Parkinsons and Its Impact on FamiliesCaring for a loved one with Parkinsons disease presents unique challenges that require both emotional resilience and practical strategies. As the disease progresses, families often find themselves in unfamiliar territory, struggling to balance their personal and professional lives while ensuring their aging loved one receives the best care possible. This article provides an in-depth look at Parkinsons disease, how it affects families, and the essential steps to prepare for the caregiving journey.What is Parkinsons Disease?Parkinsons disease is a progressive neurological disorder that primarily affects movement, but it also has cognitive and emotional implications. It occurs when dopamine-producing neurons in the brain gradually deteriorate, leading to symptoms such as tremors, muscle stiffness, slowness of movement, and balance issues. As the disease advances, individuals may experience non-motor symptoms, including depression, sleep disturbances, and cognitive decline. Understanding these symptoms is crucial for families so they can recognize early warning signs and seek appropriate medical support.The Stages of Parkinsons DiseaseParkinsons progresses in five distinct stages, each presenting different challenges for caregivers:1. Stage One (Mild Symptoms) Symptoms are mild and may only affect one side of the body. Daily activities remain largely unaffected.2. Stage Two (Moderate Symptoms) Symptoms worsen, appearing on both sides of the body. Daily tasks become slightly more challenging.3. Stage Three (Loss of Balance and Independence Challenges) Falls become more frequent, and daily activities require more effort.4. Stage Four (Severe Mobility Limitations) Assistance is needed for most daily activities, and independent living becomes difficult.5. Stage Five (Advanced Parkinsons) The individual may be bedridden or require a wheelchair, with round-the-clock care needed. Understanding these stages allows families to anticipate changes and proactively plan for caregiving needs. Emotional and Psychological Impact on FamiliesThe emotional toll of caregiving can be overwhelming, particularly for busy professionals juggling work and family responsibilities. Watching a once-independent parents who struggle with Parkinsons can evoke feelings of sadness, frustration, and guilt. Many caregivers also experience burnout due to the constant physical and emotional demands of caregiving. To manage these challenges, families should consider the following: Seek Emotional Support Support groups for Parkinsons caregivers provide a space to share experiences and receive guidance. Practice Self-Care Caregivers must prioritize their own well-being to sustain their ability to provide care. Maintain Open Communication Honest conversations among family members can help in decision-making and stress management.The Role of Professional Caregiving ServicesAs the disease progresses, family caregivers often find themselves struggling to keep up with their loved ones increasing needs. Professional caregiving services like those offered by At Your Home Caregiving of Texas LLC provides expert assistance tailored to Parkinsons patients, ensuring they receive the highest level of care while allowing family members to focus on their own professional and personal lives. Some key benefits of professional caregiving include: Personalized Care Plans Professional caregivers develop customized care strategies based on the individuals specific symptoms and progression. Mobility Assistance Helping individuals move safely, reducing the risk of falls and injuries. Medication Management Ensuring medications are taken correctly and on time. Meal Preparation and Nutrition Support Creating Parkinsons-friendly meal plans to enhance overall well-being. Companion Care Providing social interaction and engagement, reducing feelings of isolation.Available Medical Treatments and Therapies While there is no cure for Parkinsons, several treatments and therapies can help manage symptoms and improve quality of life: Medications Dopamine-enhancing medications like Levodopa help alleviate motor symptoms. Physical Therapy Helps improve balance, strength, and flexibility. Speech Therapy Addresses difficulties with speaking and swallowing. Occupational Therapy Helps individuals adapt to daily activities using assistive devices and modified techniques. Deep Brain Stimulation (DBS) A surgical procedure that can help reduce tremors and improve motor control. By incorporating these treatments into a care plan, families can improve their loved ones comfort and independence.Early Planning for a Smooth Caregiving JourneyOne of the biggest mistakes families make is waiting until a crisis occurs before seeking professional caregiving support. High-paying geriatric care clients, such as the busy professionals looking after aging parents, benefit greatly from early planning.Some key steps include: Assessing Current and Future Needs Evaluating the stage of Parkinsons and determining what level of support is required. Exploring Home Care Options Researching caregiving services that align with the familys values and expectations. Financial and Legal Planning Consulting elder law attorneys and financial advisors to create a sustainable long-term care plan. Designating a Care Coordinator Assigning a family member or professional to oversee caregiving arrangements and medical needs.By addressing these factors early, families can avoid unnecessary stress and ensure their loved ones receive seamless, high-quality care. Why Choose At Your Home Caregiving of Texas LLC?For professional families with aging parents, finding a trustworthy and compassionate caregiving service is essential. At Your Home Caregiving of Texas specializes in providing exceptional in-home care tailored to high-net-worth families. With a commitment to dignity, independence, and personalized attention, the agency offers: Highly Trained Caregivers Experienced in Parkinsons care and advanced elder care techniques. Flexible Care Plans Ranging from part-time assistance to full-time live-in care. Seamless Communication Keeping family members informed and involved in caregiving decisions. Commitment to Excellence Prioritizing client satisfaction and quality of life.Final ThoughtsParkinsons disease is a complex condition that requires a proactive and well-thought-out caregiving plan. By understanding the diseases progression, seeking the right support, and planning early, families can ensure their loved ones receive the best possible care while maintaining their own professional and personal balance.At Your Home Caregiving of Texas LLC stands ready to support families on this journey, offering specialized in-home care solutions that provide peace of mind and exceptional care for aging loved ones. This article serves as a comprehensive guide for families navigating the challenges of Parkinsons caregiving. Future articles in this series will dive deeper into specific aspects of caregiving, from hospital stays and rehabilitation to long-term care planning and caregiver well-being.
If You Have A Hearing, Vision Or Mobility Problems Accessing Or Using A Telephone - You May Qualify For A Free Telephone! 4 out of 5 Americans over the age of 60 have some hearing, vision or mobility loss. There is help however and it is paid for by you through a government program called STAP, Specialized Telecommunications Assistance Program, by a small charge each month on your telephone bill. Why not take advantage of a benefit youre paying for already? Contact Laura Carr, STAP to learn more about this program and show you what equipment youre eligible to receive FREE OF CHARGE! To qualify, you must be a Texas resident with a problem with vision, hearing or mobility. You are entitled to one FREE phone every 5 years. You can get a cell phone, landline, smartphone or tablet, depending on your disability. Must provide proof of residency. Acceptable forms of residency include:* Texas Drivers License* ID card with address* Voters Registration card* Letter from facility on their stationery* Utility Bill (current - showing address)* Vehicle registration card* Medicaid ID* Medicare Summary This program is for any Texas Resident that has a Vision, Hearing, Mobility- including cognitive problems. They are entitled to FREE telephone equipment (just the device) and they have to pay their monthly charges to their telephone service provider. Depending on their impairment, they may qualifiy for a Landline Telephone with a medical alert system; a Regular Cell Phone (where they can make calls, text, take photos including a medical alert button on the back. If they have a hearing problem, they can receive a 2-way texting device - an Android Smart Phone or Android Tablet. They have to provide their proof of residency for the State of Texas: a current drivers license, Texas ID, Voters Registration Card or a Utility bill showing their name & current address & date. Laura can assist with completing an application, take a photo of their proof of residency - attach to their signed application & send it to STAP headquarters in Austin, Texas. The State processes their application & mails the Voucher for the equipment, directly to the Resident. Once they receive the Voucher, they contact Laura and she will deliver the equipment that is authorized on the voucher to the Resident. NO MONEY CHANGES HANDS. Laura Carr, STAP Specialist has worked with this program for 16 years.Contact Laura at 214-388-0088 or LauraCarr@prodigy.net
Dont Let a Stroke Ruin Your RetirementYour risk of stroke and cardiovascular disease increases as you age. But the good news is 80% of stroke and cardiovascular disease CAN be prevented.1 If you are age 50 or older, you should be screened.Often there arent any symptoms of a stroke before it occurs, in fact for 4 out of 5 people who have a stroke the first symptom of any illness is the actual stroke.2 But, you can take steps to find out if youre at risk.Life Line Screening is a premier provider of preventive screenings for stroke and cardiovascular disease risk. A simple appointment can identify your risk factors and provide peace of mind or early detection.Screenings are easy, painless, non-invasive and dont require any messy prep work.Life Line Screening has over 14,000 locations across the United States so you can find one close to you.Getting screened is affordable. The most popular package at Life Line Screening includes 5 screenings in 1 appointment for $149.Get the most out of your life! Find out your stroke and cardiovascular disease risk with Life Line Screening so you can be in control and do something about it.***CLICK HERE*** to schedule your appointment! A simple screening can be worth a lifetime.1 American Heart Association https://www.heart.org/en/get-involved/advocate/federal-priorities/cdc-prevention-programs2 Hackam DG, Karpral MK, et al. Most stroke patients do not get a warning, a Population Based Cohort Study. Sept. 2009. Neurology, 73, 1074-1075.