What Causes Alzheimer's Disease - Types 3, 4, & 5

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Jul 22, 2024

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Texas - Dallas, Collin, SE Denton & Rockwall Counties , National

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In the past we have talked about and broken Alzheimer's down into multiple types.  They are:

Type 1

Type 1’s primary characteristic is inflammation. 

Type 2

Type 2’s primary characteristics are low levels of nutrients, hormone factors, and/or trophic factors. 

Type 1.5

Type 1.5’s primary characteristic is insulin resistance (DIABETES)

Here is the link if you would like to go back and read that:  https://alzheimerssurvivor.com/blogs/what-is-an-alzheimers-survivor/what-causes-alzheimers-disease

As we begin this week’s discussion, I want to remind you that Alzheimer’s Disease is not a single symptom.  Years of research show that you cannot point to one single trait as the single cause of Alzheimer’s Disease.  According to Dr. Dale Bredesen, people with Alzheimer’s Disease suffer from multiple “insults” for 20 - 30 years before developing Alzheimer’s. However, when you research what causes Alzheimer’s disease, most will tell you Alzheimer’s is a disease triggered by old age. Explaining that only people over 65 have Alzheimer’s Disease.   

When in reality, the most common person diagnosed with
Alzheimer’s Disease in 2024 is a 52-YEAR-OLD FEMALE!

Most people slowly develop Alzheimer’s Disease over 20 – 30 years. While symptoms will become apparent in a person in their 40s & 50s, the disease began when they were 22 – 32. What triggers Alzheimer’s Disease to start to develop at this age? Usually, an unhealthy lifestyle!  Such as eating too much junk food, eating fast food, not managing their weight, & developing insulin resistance. 

Recently, we broke Alzheimer’s Disease down into 5 different categories.  As I said then, I find it easier to differentiate the types and symptoms to address what caused it.  Here is a brief recap:

Type 1

Type 1’s primary characteristic is inflammation. 

Type 2

Type 2’s primary characteristics are low levels of nutrients, hormone factors, and/or trophic factors. 

Type 1.5

Type 1.5’s primary characteristic is insulin resistance (diabetes

Type 3

Type 3’s primary characteristic is exposure to toxins.

Type 4

Type 4’s primary characteristic is low blood flow to the brain.

Type 5

Type 5’s primary characteristic is brain damage.

This week we will review what causes Alzheimer’s Disease in Type 3, Type 4 & Type 5 Alzheimer’s Disease.

_______________________

TYPE 3

Type 3’s primary characteristic is exposure to toxins. 

What causes toxic Alzheimer’s?

Today toxins are everywhere. There are heavy metals in our food, mold in our houses, toxic substances in our plastic, and pollutants in the air. If you live in the US, toxin exposure is a fact of life. While these toxins certainly are not good for us, our bodies are capable of removing these substances. This is known as detoxification. It becomes a problem when more toxins are entering our bodies than we can remove, or when our body’s detoxification system is unequipped to detoxify a given substance. When this occurs for some people, they begin to develop a subtype of Alzheimer’s disease known as toxic Alzheimer’s. The most common contributors to toxic Alzheimer’s are as follows: 

Mycotoxins

Mycotoxins are a class of toxic chemicals secreted from certain types of molds. Some of the most well-documented mycotoxins include aflatoxin, ochratoxin, fumonisin, gliotoxins, and trichothecenes. These toxins are capable of disrupting neurotransmitter synthesis, depleting the body’s antioxidant reserve, impairing the blood brain barrier integrity, and even killing brain cells. Altogether, a heavy burden of mycotoxins can contribute to the onset of toxic Alzheimer's disease. 

Heavy Metals

Heavy metals are another source of chemical toxicants that can contribute to Alzheimer’s. The most common neurotoxic chemicals are lead, mercury, and arsenic. While we are still waiting on further research to clarify the role of heavy metals in Alzheimer’s Disease, this is what we know:

  • Lead - Lead is a heavy metal that readily passes through the blood brain barrier to cause direct damage to the brain. The result of lead toxicity is neuroinflammation, oxidative stress, and neurodegeneration. 
  • Mercury - Mercury disrupts the body’s natural antioxidant system and causes an accumulation of reactive oxygen species. These are destructive molecules that damage the DNA and cause all sorts of issues. In the case of Alzheimer's, mercury builds up in the brain and contributes to memory loss and personality changes.
  • Arsenic - Arsenic is a heavy metal found in the soil, air, and contaminated water. Arsenic travels through the blood and enters into various organ tissues where it stays. In the brain, arsenic disrupts the metabolism of brain cells called astrocytes. This metabolic disruption causes impairment to the central nervous system.

Other Toxins

There are many other toxins that we are exposed to in our modern world. Many of these are found in plastic products, such as bisphenol-A (BPA). Other sources include herbicides and pesticides used in agriculture. 

What are the signs and symptoms of toxic Alzheimer’s?

Toxic Alzheimer’s can be one of the hardest subtypes to diagnose. This is because different toxins affect the brain in different ways. For this reason, it is important to understand all signs and symptoms that may lead to a diagnosis. The following signs and symptoms are as outlined by Dr. Dale Bredesen as a part of the Bredesen Protocol in the book “The End of Alzheimer’s”.

  • Symptoms begin before age 65
  • Usually ApoE4 negative
  • No family history, or family history with symptoms beginning only at ages much older than the patient’s
  • Symptoms often occur around the time of menopause or andropause.
  • Depression precedes or accompanies cognitive decline
  • Headache is an early symptom, and sometimes the first.
  • Typical symptoms include executive function deficits (planning, problem solving, organizing, focusing), inability to manipulate numbers/perform calculations, trouble speaking or loss of speech, problems with visual perception, or problems with learned programs such as dressing.
  • Increased stress (e.g., loss of employment, divorce, family change) and sleep loss.
  • Exposure to mycotoxins or metals (e.g., inorganic mercury via amalgams, or organic mercury via fish) or both
  • Diagnosis of CIRS (chronic inflammatory response syndrome) with cognitive decline
  • Imaging suggests brain changes not seen in most cases of Alzheimer’s

TYPE 4

Type 4’s primary characteristic is low blood flow to the brain.

Type 4 or Vascular AD, is caused by a reduction of blood flow to the brain, which ultimately deprives the brain of essential oxygen and nutrients. The brain is an extremely vascularized tissue, meaning it requires large amounts of oxygen. A lack of oxygen to the brain leads to hypoperfusion (low blood flow) and compromises the blood-brain barrier which allows for harmful substances to leak in and damage neurons. Cerebral vasculature is extremely important as it is one way the body clears the accumulation of amyloid-beta.

CHARACTERISTICS & BIOCHEMICAL MARKERS OF TYPE 4

  • “Leakiness” present in vascular tissues.
  • Individuals with cardiovascular disease have a high risk for Type 4 Alzheimer’s.
  • These individuals do best when they prioritize healing underlying insulin resistance.

CARDIOVASCULAR HEALTH

Most people think of cardiovascular health, they only think about the heart.  However cardiovascular health extends to the entire body, including the brain. Vascular disease typically manifests in the brain as inflammation of the blood vessel lining. This inflammation has a series of negative effects such as activating the immune cells of the brain and reducing overall blood flow. Both of these are known contributors to the progression of Alzheimer’s and can increase the amount of amyloid plaque in the brain.  For this reason, there is a large crossover between the presence of cardiovascular disease and vascular Alzheimer’s. 

BLOOD BRAIN BARRIER INTEGRITY

The blood brain barrier often breaks down in those with Alzheimer’s disease. The blood brain barrier is the lining of the blood vessels around the brain that gives the brain an extra level of protection from bloodborne pathogens, & toxins. Since the blood brain barrier is so selective with what is and is not allowed to pass through, it can be a big deal when the structural integrity begins to degrade. Things that are not supposed to get into the brain begin to leak in. Nutrients that require an intact blood brain barrier to enter can no longer get in. This is why nutrients like omega-3 tend to be lower in those with blood brain barrier integrity issues. Cardiovascular health appears to play a large role in blood brain barrier breakdown with a positive ApoE4 status being highly correlated with vascular Alzheimer’s. 

TYPE 5

Type 5’s primary characteristic is brain damage.

Traumatic brain injuries can contribute to the development of Alzheimer’s disease. While it is different for each person, the consequences of these injuries may extend long after the initial symptoms subside. Traumatic Alzheimer’s is the fifth subtype of Alzheimer’s disease and is characterized by a history of head trauma.  Often leading to an earlier onset of Alzheimer’s disease. While not all head injuries lead to Alzheimer’s, traumatic Alzheimer’s symptoms usually do not appear until many years or decades after the traumatic event. 

Causes of Traumatic Alzheimer’s

The categorization of traumatic Alzheimer's disease came about after recognizing that the majority of people who suffered a mild to moderate traumatic brain injury during their lives had plaque in their brain upon autopsy, regardless of the cause of death.

Early research is beginning to explain how traumatic Alzheimer’s works, and how we can treat it. It appears that experiencing a traumatic brain injury causes acute stress to the brain and surrounding vasculature. Whether this is a one-time injury from an accident or a repeated trauma from playing sports, the brain becomes inflamed and the integrity of the blood-brain barrier begins to break down. While this reaction may subside in some people, it appears to kick-start the pathology of Alzheimer's disease in others. These are typically people who have an ApoE4 allele or have a predisposition towards inflammatory Alzheimer's disease or vascular Alzheimer's disease. For these people, a traumatic brain injury may expedite the onset of Alzheimer's Disease by years. When this occurs, the condition is classified as traumatic Alzheimer's disease. 

SIGNS AND SYMPTOMS OF TRAUMATIC ALZHEIMER’S

Signs and symptoms of traumatic Alzheimer’s will vary heavily from one person to the next. The most obvious sign would be a history of one or more traumatic brain injuries. Other than that, the signs and symptoms would depend on whether the brain injury is vascular or inflammatory. 

MISSION

The primary mission of Alzheimer’s Survivor is to communicate to everyone that there are treatments available for people experiencing Alzheimer’s Disease. 

  • There are Research solutions available for every stage of the disease
  • There are FDA-approved pharmaceuticals for every stage of the disease
  • There are Integrative Medicine solutions available for every stage of the disease

Gone are the days when there was nothing you could do to treat Alzheimer’s Disease. It is up to each individual and their family to decide what option best fits your need. 

Next week, we will begin to discuss treatments that are available to treat Alzheimer’s Disease.

Here are the links to purchase the books on Amazon and the link to Dr. Bredesen’s website.

THE END OF ALZHEIMER’S 2 BOOKS COLLECTION SET BY DALE BREDESEN PAPERBACK – OCTOBER 26, 2023

LINK:

https://amzn.to/462LcY3

The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at AnyAge Paperback – September 6, 2022

LINK:

https://amzn.to/3xNcrct

Dr. Bredesen’s Website

LINK: https://www.apollohealthco.com/

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What Causes Alzheimer's Disease - Types 1, 2 & 1.5

Alzheimers Disease is not a single thing.  Years of research show that you cannot point to 1 single thing as the cause of Alzheimers Disease.  For years the healthcare industry agreed that the unifying component of Alzheimers Disease was age.  Sadly, many groups still define Alzheimers Disease as an old age disease.  When in reality the most common person diagnosed with Alzheimers Disease is a 52-year-old female (example picture below).Alzheimers Disease is not something you will wake up with one day after you turn 80 (example picture below).  Most people slowly develop Alzheimers Disease over 20 30 years. 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There are two types: acute and chronic. You're probably more familiar with the acute type, which occurs when you bang your knee or cut your finger. Your immune system dispatches an army of white blood cells to surround and protect the area, creating visible redness and swelling. The process works similarly if you have an infection like the flu or pneumonia. So in these settings, inflammation is essentialwithout it, injuries could fester and simple infections could be deadly.The inflammation could come from many different factors. It may start from a leaky gut, chronic sinusitis, a poor oral microbiome with chronic poor oral health. It can be a systemic infection or any number of other undiagnosed chronic infections. Any of these things can contribute to inflammation in your body.Types of InflammationAcute InflammationAcute inflammation is a healthy and necessary function that helps the body attack bacteria and other foreign substances in the body. Once the body has healed, the inflammation resolves. Acute inflammation can cause heat or warmth in the affected area. For example, an injured part of your body might feel warm to the touch. Sometimes, the heat is caused by a fever.A few examples of common conditions that can cause acute inflammation include:Acute bronchitis An infected body partA sore throat related to the flu or another viral infection Dermatitis Physical traumaSinusitis Skin cuts and scratches Chronic InflammationChronic inflammation may continue to attack healthy areas if it doesn't "turn off." It may not be as visible as acute inflammation. A few examples of chronic inflammatory conditions include:Inflammatory arthritis (including rheumatoid arthritis, lupus, and psoriatic arthritis)Asthma Periodontitis (inflammation of gums and other supporting teeth structures)Inflammatory bowel disease (including Crohns disease and ulcerative colitis, which cause signs of inflammation in the GI tract)Eczema  Issues with chronic inflammation tend to run in families as it is common in people who carry one or two ApoE4 alleles (ApoE in itself is considered an inflammatory gene). Type 2Type 2s primary characteristic is low levels of nutrients, hormone imbalances, and/or trophic factors. MalnutritionWhy would someone living in a wealthy first-world country experience low levels of nutrition? While most people in the US have plenty to eat. 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Regular monitoring of blood sugar levels, adherence to treatment plans, and lifestyle modifications are essential for effectively managing the condition.If you find that you are experiencing symptoms consistent with diabetes you must see an endocrinologist!  Much has changed in the world of diabetes management in the last 5 years.  Primary Care Providers are amazing doctors.  I believe they do not have the experience and training required to treat diabetes. I confidently say this from my own experience.  I was officially diagnosed as a Type 2 diabetic in 2019.  When I was diagnosed my blood sugar was out of control!  I had highs that would startle you!  The truth is, I had those highs for years I just did not know it.  I did not have health insurance and denied the truth to myself.  Once diagnosed I found a very well-respected primary care doctor.  He and his nurses worked with me to teach me the importance of checking my blood sugar twice a day.  I was instructed to begin injecting a long-acting insulin every night about 2 hours after I ate.  My blood sugar came down and I was encouraged to keep my A1C at or about 7.  My doctor and his staff were following the current protocols.  Then Covid hit and the world fell apart.My primary care provider was not accepting appointments, returning calls, or refilling prescriptions.  Two weeks of lockdowns were quickly extended to months of lockdowns.  For me, that was months of lockdowns without the medication I needed.  I left that provider and started working with another.  This time a much more respected doctor and his staff of PAs.  Both providers assumed that since I am an adult in my 50s, I am a type 2 diabetic.  They carefully evaluated me changed my medication and added Ozempic to the mix. Again, following the appropriate protocols they researched and were confident were the best solutions for type 2 diabetes.Over the next 6 months, I experienced unbelievable GI pain and constant issues.  I begged for referrals to a GI doctor but was denied.  I only lost 7 pounds on Ozempic, my blood sugar was steadily inching up, I had COVID-19, and was simply miserable. Until one day after not being able to keep anything down for a few days and unbelievable pain, I went to the ER.  Finally, with the results from the CT scan, I found a new primary care doctor.  This guy was horrible and mismanaged my diabetes worse than ever before.  However, he did not deny the referral to a GI doctor. I waited months to get in and even longer to get the tests I needed to learn what was going on inside of my gut. But he was the one who said I needed an Endocrinologist and demanded that my doctor write the referral to the doctor I work with now.Between the GI doctor and my Endocrinologist, I learned that I am not a Type 2 diabetic.  I am a Type 1.5 diabetic or an adult with Type 1 diabetes.  My GI issues have been resolved with lifestyle and nutritional changes.  I was prescribed an OmniPod 5 insulin pump and a constant glucose monitoring device (gcm).  My blood sugar ranges between 95 and 105 all day except after I eat my 1 meal a day. But the highs after I eat are much lower than my lowest reading before I started receiving the appropriate care. I tell you this to say your Primary Care Provider is not a bad doctor.  They are providing the care they are told to provide.  However, they are not experts in diabetes management.  My research and personal experience say:If you look down and cannot see your toes, you need a very thorough evaluation for insulin resistance. If you have skin tags, you need a very thorough evaluation for insulin resistance. If you are always thirsty, you need a very thorough evaluation for insulin resistance. If you crave sugary food, you need a very thorough evaluation for insulin resistance. If you get up to pee more than once at night, you need a very thorough evaluation for insulin resistance. Fasting glucose tests or a simple A1C test are not enough.  You need to wear a constant glucose monitoring device for at least 10 days.  Your doctor will see your accurate highs and lows and have better information to diagnose you and create a treatment plan.Demand your primary care provider provide you with the referral.  Your brain health depends on it!I still encourage you to purchase Dr. Dale Bredesens books.  Or go to his website and read through everything. If not for yourself, for a friend or family member. 1 in 3 people will die from Alzheimers Disease. We all must do what we can to reduce those numbers. Here are the links to purchase the books on Amazon and the link to Dr. Bredesens website.THE END OF ALZHEIMERS 2 BOOKS COLLECTION SET BY DALE BREDESEN PAPERBACK OCTOBER 26, 2023LINK:https://amzn.to/462LcY3 The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at AnyAge Paperback September 6, 2022LINK:https://amzn.to/3xNcrctDr. Bredesens WebsiteLINK: https://www.apollohealthco.com/