The Success of Lecanumab (Leqembi) in Treating Alzheimer's Disease
Kathleen Warshawsky, BSN, RN
For more information about the author, click to view their website: Seniors Blue Book Greater Dallas
Feb 06, 2023
Non-Book Market , Texas - Dallas, Collin, SE Denton & Rockwall Counties
The Success of Lecanumab (Leqembi) in Treating Alzheimer's Disease
Alzheimer's disease is a debilitating and progressive brain disorder that affects more than 6.5 million Americans. It slowly erodes memory and thinking skills, and eventually the ability to carry out simple tasks. Despite the efforts of researchers and scientists, the specific causes of Alzheimer's disease are still not fully known. However, the disease is characterized by changes in the brain such as amyloid beta plaques and neurofibrillary tangles that result in the loss of neurons and their connections. These changes impact a person's ability to remember and think, leading to a decline in cognitive function.
Leqembi, also known as lecanemab-irmb, is a new treatment for Alzheimer's disease that as of January 6th, 2023, has been approved by the U.S. Food and Drug Administration (FDA) through the Accelerated Approval pathway. This new treatment represents an important advancement in the ongoing battle against Alzheimer's disease, as it targets the fundamental pathophysiology of the disease, rather than merely treating its symptoms.
Leqembi's efficacy was evaluated in a double-blind, placebo-controlled, parallel-group, dose-finding study of 856 patients with Alzheimer's disease. The study showed that patients receiving the approved dose of Leqembi (10 milligrams/kilogram every two weeks) had a statistically significant reduction in brain amyloid plaque compared to the placebo arm. The amyloid beta plaque was quantified using positron emission tomography (PET) imaging, and was estimated in a composite of brain regions that are expected to be widely affected by Alzheimer's disease pathology.
The results of this study support the accelerated approval of Leqembi, which is based on the observed reduction of amyloid beta plaque, a marker of Alzheimer's disease. The prescribing information for Leqembi includes a warning for amyloid-related imaging abnormalities (ARIA) and a risk of infusion-related reactions. However, the most common side effects of Leqembi were infusion-related reactions, headache, and ARIA.
The FDA granted Leqembi Fast Track, Priority Review, and Breakthrough Therapy designations, highlighting the significance of this new treatment for Alzheimer's disease. Leqembi's approval marks a major milestone in the fight against Alzheimer's disease, providing hope for patients and their families who have been affected by this devastating condition.
Leqembi has been proven to be an effective treatment for Alzheimer's disease, offering a new hope for patients and their families. The results of the clinical trial demonstrate a significant reduction in brain amyloid plaque, a hallmark of Alzheimer's disease, and provide a strong foundation for further research and development in this field.
References:
· U.S. Food and Drug Administration. (2023, January 6). FDA Grants Accelerated Approval for Alzheimer’s Disease Treatment. [Press Release]. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-disease-treatment
· Leqembi. (n.d.). Medication Guide. Retrieved from https://www.leqembi.com/-/media/Files/Leqembi/Medication-Guide.pdf?hash=d4e8f584-6cf3-41c4-a7f3-34bda6abb800
Author: Kathleen Warshawsky, BSN, RN | Publisher Seniors Blue Book Greater Dallas | https://www.linkedin.com/in/kathleenwbsnrn/
Other articles you may like:
Aducanumab and Lecanemab: How are they different?
The Success of Lecanumab (Leqembi) in Treating Alzheimer's Disease
The Success of Aducanumab in Treating Alzheimer's Disease
Other Articles You May Like
Patient & Family Care at Vincentian
At Vincentian, Patient and Family Centered Care is a fundamental approach that shapes every aspect of healthcare delivery. This philosophy places individuals at the heart of all decisions and actions, recognizing that each person has unique needs, preferences, and communication styles.Core PrinciplesThe cornerstone of this approach is the partnership between caregivers, patients, residents, and their families. This collaborative model ensures that care is tailored to individual needs, promoting not just health but overall thriving.Understanding the Patient ExperienceTo truly grasp the patient and resident experience, Vincentian employs several strategies:Shadowing: Staff members may follow patients or residents throughout their day to gain firsthand insights into their experiences.Observation: Careful monitoring of daily routines and interactions helps identify areas for improvement.Continuous Learning: The organization maintains an open dialogue with those they serve, constantly adapting to feedback and new information.Practical ApplicationsPatient and Family Centered Care manifests in various practical ways:Personalized Scheduling: Therapy sessions are arranged around preferred mealtimes or sleep patterns.Tailored Welcome: New residents receive personalized invitations to activities matching their interests.Flexible Care Plans: Care routines are adjusted to accommodate individual preferences and habits.Fostering ConnectionVincentian recognizes that the need for human connection doesn't diminish with age or in care settings; in fact, it becomes even more crucial. Their approach emphasizes:Intergenerational Interaction: Programs that bring together different age groups, fostering mutual learning and growth.Holistic Wellness: Strategies addressing all aspects of well-being, from physical health to social and emotional needs.Community Building: Creating environments where residents don't just coexist but thrive together.Designing for Individual NeedsThe organization goes beyond basic care to create living spaces that truly feel like home. This is achieved through:Resident Councils: Groups that provide input on community decisions and improvements.Experience Workgroups: Teams dedicated to enhancing the overall resident experience.Adaptive Design: Spaces and programs that evolve based on resident feedback and changing needs.Inclusive EnvironmentVincentian strives to create an atmosphere that is welcoming and accommodating to all. This includes:Diverse Programming: Activities and events that cater to a wide range of interests and abilities.Accessible Spaces: Physical environments designed to be navigable by residents with varying levels of mobility.Cultural Sensitivity: Recognition and celebration of the diverse backgrounds of residents and staff.Continuous ImprovementThe organization maintains a commitment to ongoing enhancement of their care model. This involves:Regular Feedback Loops: Mechanisms for residents and families to share their experiences and suggestions.Staff Training: Continuous education for caregivers on the principles of Patient and Family Centered Care.Innovation in Care: Exploring new technologies and methodologies to improve care delivery and resident quality of life.By embracing this comprehensive approach to Patient and Family Centered Care, Vincentian creates a nurturing environment where individuals are not just cared for but truly valued and empowered. This model recognizes that each person's journey is unique, and by tailoring care to individual needs and preferences, Vincentian helps ensure that every resident can live their life to the fullest, maintaining dignity, autonomy, and a sense of community throughout their care journey. Give them a call today to learn more about what makes them different.
Memory Care: Maintaining Dignity with Independence
Memory care facilities play a crucial role in maintaining the independence and dignity of seniors living with cognitive impairments. For families seeking an assisted living facility in Burnsville, Minnesota, understanding how these facilities encourage self-sufficiency can provide peace of mind. Personalized Care Plans Each resident in a memory care facility receives a personalized care plan that caters to their unique needs. These plans are designed to balance support with opportunities for independence, ensuring that seniors engage in daily activities that promote self-reliance. This approach is integral to providing high-quality senior care in Minnesota. Structured Routines Memory care facilities implement structured routines that help residents maintain a sense of control over their lives. Predictable schedules and familiar environments allow seniors to manage their daily tasks with minimal assistance, fostering a sense of autonomy. This structured yet flexible environment is a hallmark of facilities offering waivered care services. Engaging Activities Regularly scheduled activities tailored to residents abilities are a cornerstone of memory care. These activities not only stimulate cognitive function but also encourage social interaction and personal growth. Residents are often given choices in their activities, which further reinforces their independence. Supportive Environment The physical design of memory care facilities is intentionally crafted to promote safe navigation and ease of movement. Clear pathways, labeled rooms, and accessible outdoor spaces allow residents to explore their surroundings confidently, reducing the need for constant supervision. This supportive environment is critical in offering 24 hour care without compromising independence. Dignity through Respectful Care Staff members in memory care facilities are trained to provide care that respects each residents dignity. This includes encouraging participation in personal care routines and respecting residents choices, which are essential in preserving their self-esteem and dignity. Memory care facilities like Cardenas Friendship Homes are dedicated to enhancing the quality of life for seniors. Families looking for compassionate care should contact us to learn more about our services.
Wellness and Community in Senior Living
Finding the perfect balance between wellness and community is essential for a fulfilling senior living experience. At an assisted living facility in Burnsville, Minnesota, residents enjoy a supportive environment where their health and social needs are prioritized. These facilities are designed to offer more than just assistance with daily activitiesthey provide a vibrant community where seniors can thrive, stay active, and enjoy meaningful interactions.When it comes to senior care in Minnesota, choosing the right environment can make all the difference. Facilities in Minnesota focus on delivering personalized care plans that address both physical and emotional well-being. From tailored health services to engaging activities, these care facilities ensure that seniors receive the attention they need while also fostering a sense of belonging and community.For those needing specialized support, waivered care services are an integral part of senior care. These services offer customized assistance for individuals with specific needs, such as advanced medical conditions or unique personal preferences. By incorporating waivered care into their senior living options, facilities can provide more comprehensive care solutions that cater to each residents requirements, enhancing their overall quality of life.Ultimately, senior living is about creating a space where wellness and community come together harmoniously. By choosing a facility that prioritizes both, seniors can enjoy a rich, fulfilling lifestyle surrounded by supportive peers and compassionate caregivers. Its about more than just meeting basic needsits about nurturing a thriving, engaged community that supports each residents unique journey.If youre looking for a senior living community where wellness meets community, contact Cardenas Friendship Homes today to explore our comprehensive care options and discover how we can support your loved ones needs.
Local Services By This Author
STAP (Specialized Telephone Assistive Program)
Hearing/Deaf Products , , Texas,If You Have A Hearing, Vision Or Mobility Problems Accessing Or Using A Telephone - You May Qualify For A Free Telephone! 4 out of 5 Americans over the age of 60 have some hearing, vision or mobility loss. There is help however and it is paid for by you through a government program called STAP, Specialized Telecommunications Assistance Program, by a small charge each month on your telephone bill. Why not take advantage of a benefit youre paying for already? Contact Laura Carr, STAP to learn more about this program and show you what equipment youre eligible to receive FREE OF CHARGE! To qualify, you must be a Texas resident with a problem with vision, hearing or mobility. You are entitled to one FREE phone every 5 years. You can get a cell phone, landline, smartphone or tablet, depending on your disability. Must provide proof of residency. Acceptable forms of residency include:* Texas Drivers License* ID card with address* Voters Registration card* Letter from facility on their stationery* Utility Bill (current - showing address)* Vehicle registration card* Medicaid ID* Medicare Summary This program is for any Texas Resident that has a Vision, Hearing, Mobility- including cognitive problems. They are entitled to FREE telephone equipment (just the device) and they have to pay their monthly charges to their telephone service provider. Depending on their impairment, they may qualifiy for a Landline Telephone with a medical alert system; a Regular Cell Phone (where they can make calls, text, take photos including a medical alert button on the back. If they have a hearing problem, they can receive a 2-way texting device - an Android Smart Phone or Android Tablet. They have to provide their proof of residency for the State of Texas: a current drivers license, Texas ID, Voters Registration Card or a Utility bill showing their name & current address & date. Laura can assist with completing an application, take a photo of their proof of residency - attach to their signed application & send it to STAP headquarters in Austin, Texas. The State processes their application & mails the Voucher for the equipment, directly to the Resident. Once they receive the Voucher, they contact Laura and she will deliver the equipment that is authorized on the voucher to the Resident. NO MONEY CHANGES HANDS. Laura Carr, STAP Specialist has worked with this program for 16 years.Contact Laura at 214-388-0088 or LauraCarr@prodigy.net
Lifeline Screening
Medical & Wellness , , ,Dont Let a Stroke Ruin Your RetirementYour risk of stroke and cardiovascular disease increases as you age. But the good news is 80% of stroke and cardiovascular disease CAN be prevented.1 If you are age 50 or older, you should be screened.Often there arent any symptoms of a stroke before it occurs, in fact for 4 out of 5 people who have a stroke the first symptom of any illness is the actual stroke.2 But, you can take steps to find out if youre at risk.Life Line Screening is a premier provider of preventive screenings for stroke and cardiovascular disease risk. A simple appointment can identify your risk factors and provide peace of mind or early detection.Screenings are easy, painless, non-invasive and dont require any messy prep work.Life Line Screening has over 14,000 locations across the United States so you can find one close to you.Getting screened is affordable. The most popular package at Life Line Screening includes 5 screenings in 1 appointment for $149.Get the most out of your life! Find out your stroke and cardiovascular disease risk with Life Line Screening so you can be in control and do something about it.***CLICK HERE*** to schedule your appointment! A simple screening can be worth a lifetime.1 American Heart Association https://www.heart.org/en/get-involved/advocate/federal-priorities/cdc-prevention-programs2 Hackam DG, Karpral MK, et al. Most stroke patients do not get a warning, a Population Based Cohort Study. Sept. 2009. Neurology, 73, 1074-1075.