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The Success of Lecanumab (Leqembi) in Treating Alzheimer's Disease
Alzheimer's disease is a debilitating and progressive brain disorder that affects more than 6.5 million Americans. It slowly erodes memory and thinking skills, and eventually the ability to carry out simple tasks. Despite the efforts of researchers and scientists, the specific causes of Alzheimer's disease are still not fully known. However, the disease is characterized by changes in the brain such as amyloid beta plaques and neurofibrillary tangles that result in the loss of neurons and their connections. These changes impact a person's ability to remember and think, leading to a decline in cognitive function.
Leqembi, also known as lecanemab-irmb, is a new treatment for Alzheimer's disease that as of January 6th, 2023, has been approved by the U.S. Food and Drug Administration (FDA) through the Accelerated Approval pathway. This new treatment represents an important advancement in the ongoing battle against Alzheimer's disease, as it targets the fundamental pathophysiology of the disease, rather than merely treating its symptoms.
Leqembi's efficacy was evaluated in a double-blind, placebo-controlled, parallel-group, dose-finding study of 856 patients with Alzheimer's disease. The study showed that patients receiving the approved dose of Leqembi (10 milligrams/kilogram every two weeks) had a statistically significant reduction in brain amyloid plaque compared to the placebo arm. The amyloid beta plaque was quantified using positron emission tomography (PET) imaging, and was estimated in a composite of brain regions that are expected to be widely affected by Alzheimer's disease pathology.
The results of this study support the accelerated approval of Leqembi, which is based on the observed reduction of amyloid beta plaque, a marker of Alzheimer's disease. The prescribing information for Leqembi includes a warning for amyloid-related imaging abnormalities (ARIA) and a risk of infusion-related reactions. However, the most common side effects of Leqembi were infusion-related reactions, headache, and ARIA.
The FDA granted Leqembi Fast Track, Priority Review, and Breakthrough Therapy designations, highlighting the significance of this new treatment for Alzheimer's disease. Leqembi's approval marks a major milestone in the fight against Alzheimer's disease, providing hope for patients and their families who have been affected by this devastating condition.
Leqembi has been proven to be an effective treatment for Alzheimer's disease, offering a new hope for patients and their families. The results of the clinical trial demonstrate a significant reduction in brain amyloid plaque, a hallmark of Alzheimer's disease, and provide a strong foundation for further research and development in this field.
References:
· U.S. Food and Drug Administration. (2023, January 6). FDA Grants Accelerated Approval for Alzheimer’s Disease Treatment. [Press Release]. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-disease-treatment
· Leqembi. (n.d.). Medication Guide. Retrieved from https://www.leqembi.com/-/media/Files/Leqembi/Medication-Guide.pdf?hash=d4e8f584-6cf3-41c4-a7f3-34bda6abb800
Author: Kathleen Warshawsky, BSN, RN | Publisher Seniors Blue Book Greater Dallas | https://www.linkedin.com/in/kathleenwbsnrn/
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Understanding Dementia and the Importance of Care at HomeDementia is a complex condition that affects millions of individuals and their families worldwide. It encompasses a range of cognitive impairments that can significantly impact daily life, making it essential to understand its nuances and the importance of specialized care for those affected. Homewatch CareGivers of Boulder stands out as a trusted provider of memory care at home, dedicated to supporting dementia patients and their families.Dementia is not a single disease, but a term that describes a range of symptoms associated with a decline in cognitive function. It includes various types, such as Alzheimer's disease, vascular dementia, and Lewy body dementia.Individuals with dementia often face common challenges, such as memory loss, difficulty communicating, and impaired reasoning. These challenges can lead to emotional and psychological effects not only on patients, but also on their families, creating a ripple effect of stress and uncertainty.The Benefits of Specialized Home CareOne of the most significant advantages of specialized home care is the development of personalized care plans. At Homewatch CareGivers of Boulder, we recognize that each individual has unique needs. Our caregivers work closely with family members to tailor care that best suits the patient, ensuring that their specific requirements are met. This collaborative approach fosters a sense of inclusion and empowerment among family members, making them active participants in the care process.Additionally, staying in a familiar environment can have a profound impact on dementia patients. Home is where they feel safe and secure, and staying in such a setting can help reduce confusion and anxiety. By providing care at home, we can create a calming atmosphere that encourages comfort and stability.Trained Caregivers for Compassionate SupportOur caregivers are specially trained in dementia care, equipped with the expertise needed to support patients effectively. They possess not only the skills required for daily care but also the empathy and understanding necessary to address the emotional needs of those they care for. Continuous training and support ensure that our caregivers stay updated on the best practices in dementia care, promoting high-quality support for every patient.Enhancing Quality of LifeQuality of life is paramount for dementia patients, and specialized home care plays a crucial role in enhancing it. Our caregivers provide engaging activities and opportunities for social interaction, helping patients stay connected and active.Maintaining daily routines and promoting independence are also key elements of our approach, as they instill a sense of normalcy and purpose in the lives of our clients. Moreover, we offer support to family members, helping them navigate the challenges of caregiving and ensuring they have the resources they need.Reach Out TodaySpecialized home care for dementia patients offers numerous benefits, from personalized care plans to the comfort of a familiar environment. Homewatch CareGivers of Boulder is committed to delivering high-quality memory care tailored to individual needs. We encourage you to consider our services as an option for their loved ones facing the challenges of dementia. Call us with any questions, 844-908-3819.
Communicating Beyond Words: 6 Dementia Communication TechniquesCaring for someone with dementia is a profound and emotional experience. Dementia impacts how individuals process and express thoughts, making communication challenging. Yet, as words become elusive, connections can still flourish through compassionate and effective dementia communication techniques.At Community Senior Life, we provide memory care services throughout Alabama and are committed to providing family members and caregivers with practical and effective strategies to communicate beyond words alone. Our team is sharing some of these dementia communication techniques to enhance your and your family members connection.The Importance of Non-Verbal CommunicationWhen verbal communication falters, nonverbal techniques offer a lifeline. Learning and incorporating nonverbal communication becomes essential. Simple gestures, expressions like a warm smile, familiar surroundings, music, and other nonverbal cues bridge gaps in understanding, providing comfort and connection. Leveraging these cues can create a more nurturing and supportive setting to help individuals feel seen and valued.6 Effective and Compassionate TechniquesUse Body LanguageBody language is one of the most powerful dementia communication techniques. Maintain an open posture, face the person directly, and use calm, slow movements. Avoid crossing your arms or displaying impatience, as these can create barriers and increase feelings of frustration or isolation. Instead, extend a hand or offer a gentle touch to show support and encouragement. Smiling and nodding can also help convey warmth and understanding, making the person feel more comfortable and valued.Create a Familiar SettingMaintaining a space that feels familiar can help your family member feel safe and ease anxiety. Surround your loved one with cherished items, photographs, and comforting scents that evoke positive memories and a sense of home. Consistent routines provide a sense of stability, reducing confusion and creating a predictable setting. Incorporating daily rituals, like having a cup of tea at the same time each day, can further enhance their sense of security and familiarity.Music for Mood and MemoryMusic is another one of the profoundly effective dementia communication techniques. Music can evoke emotions, trigger memories, and create connections that transcend verbal communication. Play familiar tunes or songs from their youth to stimulate joy and engagement. Encourage gentle humming or tapping along, fostering a shared moment of happiness and connection. Simple instrument playing or sing-alongs can further engage a family member with dementia in a therapeutic and enjoyable manner.Eye Contact and Facial ExpressionsEye contact can convey presence and attentiveness, making a family member with dementia feel valued and recognized. Combine this with warm, expressive facial expressions to show empathy and understanding. Smiles, nods, and soft gazes can transcend verbal limitations, bridging emotional gaps and fostering a deeper connection. Additionally, mirroring their expressions and emotions can help them feel understood and connected, reinforcing their sense of self-worth and significance.Voice Tone and Personal AppearanceA gentle, soothing tone of voice can reassure and calm individuals with dementia. Speak slowly and clearly, using simple phrases and pausing to allow them time to process information. Your personal appearance also matters; dressing neatly and maintaining a clean, welcoming demeanor can make interactions more pleasant and respectful. These elements combine to create a comforting presence, helping to set a positive tone for communication and interaction.Giving Personal SpaceWhile engagement is vital, an often overlooked dementia communication technique is simply providing space and respecting privacy. Allow your relative moments of solitude, ensuring they feel autonomous and dignified. Providing opportunities for independent tasks, such as simple occupations or hobbies, can enhance their sense of self and purpose. Balancing interaction with independence fosters a respectful and empathetic relationship, ensuring that their needs for both connection and privacy are adequately met.Enhancing communication with people we love and who have been diagnosed with Alzheimers disease or any other form of dementia requires patience, empathy, and creativity. Compassionate care is the foundation of our memory care communities in Alabama, enriching lives and nurturing bonds. Are you ready to enhance your communication with those close to your heart? Contact a member at 251-981-0200 of the Community Senior Life team to learn more about our programs, amenities, and services. Better yet, schedule a tour at any of our memory care communities in Alabama to discover how our compassionate caregivers can support your family member and provide them with a dignified lifestyle.
Chronic pain is a significant challenge for many seniors, affecting up to 75% of those over 65. This persistent discomfort can lead to a sedentary lifestyle, which in turn may contribute to depression, mood swings, and decreased strength and mobility. As a result, daily activities and cherished hobbies can become difficult to enjoy. However, research shows that exercise can be an effective self-management strategy for chronic pain. Studies indicate that seniors who engage in at least two hours of weekly exercise may experience up to 25% less joint and muscle pain compared to their inactive peers. This is particularly relevant for those with conditions like osteoporosis or arthritis.The Centers for Disease Control and Prevention (CDC) recommends that older adults aim for 150 minutes of moderate aerobic exercise each week, along with some strength training. This could involve several half-hour walks or a few morning jogs. Resistance training is also beneficial for improving strength, flexibility, and balance, which can help reduce the risk of falls and fractures.For seniors dealing with chronic lower back pain, joint osteoarthritis, or diabetes-related pain, these goals might seem daunting. However, any movement that transitions from sedentary to active can help manage pain. Staying still often worsens chronic pain symptoms, while increased physical activity can significantly reduce ongoing discomfort and help the body adapt to common pain triggers.Regular exercise offers numerous benefits for seniors, including:Maintaining functional joint movementIncreasing mobility and flexibilityImproving cardiovascular health and staminaPreventing the breakdown of bone and cartilage tissueIt's important to remember that physical activity doesn't have to mean intense workouts. For seniors, any form of body movement is beneficial. Here are some tips for staying active:Make exercise social: Invite a friend for a walk, join a community dance class, or incorporate movement into family visits.Keep it fun: Find enjoyable activities that incorporate strength, endurance, balance, and flexibility.Set short-term goals and track progress: This can boost motivation and consistency.Many senior living communities, like those operated by Priority Life Care, offer daily exercise classes and social events to keep residents active. These classes can be modified to accommodate various fitness levels, making them accessible to all. They also provide opportunities to find workout buddies for added motivation.By embracing regular physical activity, seniors can gain confidence in managing their pain and improve their overall well-being. The key is to remain as active as current abilities allow, gradually building strength and endurance over time. With persistence and the right approach, chronic pain doesn't have to be a barrier to an active, fulfilling lifestyle in the golden years.FITNESS AND SENIOR LIVING COMMUNITIESPriority Life Care Senior Living Communities offer daily exercise classes as well as social events that can keep you moving. Classes are easily modified to accommodate any level of fitness. Its a great way to keep active and find a fitness buddy to keep you motivated. If you are looking to do a specific type of exercise that is not offered, let the Life Enrichment Director know! We often find if one person is asking for something specific, there are other like-minded individuals who will also participate. Visit a Priority Life Care community today to see what is available for you.
If You Have A Hearing, Vision Or Mobility Problems Accessing Or Using A Telephone - You May Qualify For A Free Telephone! 4 out of 5 Americans over the age of 60 have some hearing, vision or mobility loss. There is help however and it is paid for by you through a government program called STAP, Specialized Telecommunications Assistance Program, by a small charge each month on your telephone bill. Why not take advantage of a benefit youre paying for already? Contact Laura Carr, STAP to learn more about this program and show you what equipment youre eligible to receive FREE OF CHARGE! To qualify, you must be a Texas resident with a problem with vision, hearing or mobility. You are entitled to one FREE phone every 5 years. You can get a cell phone, landline, smartphone or tablet, depending on your disability. Must provide proof of residency. Acceptable forms of residency include:* Texas Drivers License* ID card with address* Voters Registration card* Letter from facility on their stationery* Utility Bill (current - showing address)* Vehicle registration card* Medicaid ID* Medicare Summary This program is for any Texas Resident that has a Vision, Hearing, Mobility- including cognitive problems. They are entitled to FREE telephone equipment (just the device) and they have to pay their monthly charges to their telephone service provider. Depending on their impairment, they may qualifiy for a Landline Telephone with a medical alert system; a Regular Cell Phone (where they can make calls, text, take photos including a medical alert button on the back. If they have a hearing problem, they can receive a 2-way texting device - an Android Smart Phone or Android Tablet. They have to provide their proof of residency for the State of Texas: a current drivers license, Texas ID, Voters Registration Card or a Utility bill showing their name & current address & date. Laura can assist with completing an application, take a photo of their proof of residency - attach to their signed application & send it to STAP headquarters in Austin, Texas. The State processes their application & mails the Voucher for the equipment, directly to the Resident. Once they receive the Voucher, they contact Laura and she will deliver the equipment that is authorized on the voucher to the Resident. NO MONEY CHANGES HANDS. Laura Carr, STAP Specialist has worked with this program for 16 years.Contact Laura at 214-388-0088 or LauraCarr@prodigy.net
Dont Let a Stroke Ruin Your RetirementYour risk of stroke and cardiovascular disease increases as you age. But the good news is 80% of stroke and cardiovascular disease CAN be prevented.1 If you are age 50 or older, you should be screened.Often there arent any symptoms of a stroke before it occurs, in fact for 4 out of 5 people who have a stroke the first symptom of any illness is the actual stroke.2 But, you can take steps to find out if youre at risk.Life Line Screening is a premier provider of preventive screenings for stroke and cardiovascular disease risk. A simple appointment can identify your risk factors and provide peace of mind or early detection.Screenings are easy, painless, non-invasive and dont require any messy prep work.Life Line Screening has over 14,000 locations across the United States so you can find one close to you.Getting screened is affordable. The most popular package at Life Line Screening includes 5 screenings in 1 appointment for $149.Get the most out of your life! Find out your stroke and cardiovascular disease risk with Life Line Screening so you can be in control and do something about it.***CLICK HERE*** to schedule your appointment! A simple screening can be worth a lifetime.1 American Heart Association https://www.heart.org/en/get-involved/advocate/federal-priorities/cdc-prevention-programs2 Hackam DG, Karpral MK, et al. Most stroke patients do not get a warning, a Population Based Cohort Study. Sept. 2009. Neurology, 73, 1074-1075.