ADEPT-4 Clinical Research Study: Advancing Care for Alzheimer’s Diseas
Aqualane Clinical Research
For more information about the author, click to view their website: Aqualane Clinical Research
Mar 11, 2026
Florida - Southwest
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Alzheimer’s disease affects millions of families across the United States, bringing challenges that extend far beyond memory loss. For many individuals, the condition can also lead to psychosis, which may include hallucinations, delusions, and changes in perception. These symptoms can be distressing for both the person living with Alzheimer’s and the caregivers who support them.
The ADEPT-4 clinical research study is working to advance understanding and treatment options for Alzheimer’s Disease Psychosis (ADP). Conducted by Aqualane Clinical Research in Naples, Florida, the study is currently seeking qualified participants to help evaluate potential new therapies aimed at improving quality of life for those affected by this condition.
Understanding Psychosis in Alzheimer’s Disease
Psychosis associated with Alzheimer’s disease can appear in the later stages of the condition and may involve:
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Seeing or hearing things that are not present (hallucinations)
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Believing things that are not true (delusions)
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Increased confusion or paranoia
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Changes in behavior that can be distressing for caregivers and loved ones
These symptoms can make daily life more challenging and may increase caregiver stress. While treatments exist, researchers continue to search for safer and more effective options that specifically address psychosis in people living with Alzheimer’s.
Clinical research studies like ADEPT-4 play a critical role in discovering these solutions.
Who May Qualify for the ADEPT-4 Study
Individuals may be eligible to participate if they meet certain criteria, including:
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Age between 55 and 90 years old
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Diagnosis of mild to severe Alzheimer’s disease
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Moderate to severe psychosis, including hallucinations and/or delusions
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A caregiver who can attend study visits, help report on the patient’s condition, oversee medications and treatment, and assist with written assessments
Caregiver participation is an important part of the study, helping researchers understand how symptoms affect daily life and how treatments may improve patient outcomes.
Why Clinical Research Matters
Clinical research studies help physicians and scientists develop new treatments, medications, and care strategies that can improve the lives of patients and families facing complex medical conditions.
By participating in a clinical trial like ADEPT-4, individuals and caregivers may:
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Contribute to the advancement of Alzheimer’s disease research
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Help researchers develop future treatment options
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Receive study-related care and monitoring from experienced medical professionals
While participation is voluntary, every clinical study plays an important role in shaping the future of healthcare.
Learn More About Participating
If you or someone you care for may qualify for the ADEPT-4 Alzheimer’s Disease Psychosis Treatment Program, the team at Aqualane Clinical Research can provide more information and determine eligibility.
Aqualane Clinical Research
📍 3200 Bailey Ln, Suite 250
Naples, FL 34105
📞 (239) 529-6780
Their experienced research team can answer questions, explain the study process, and help families decide if participation may be right for them.
Moving Alzheimer’s Research Forward
Alzheimer’s disease continues to impact millions of individuals and families. Clinical studies like ADEPT-4 represent an important step toward better understanding the condition and developing therapies that improve the lives of those affected.
For families navigating Alzheimer’s disease and psychosis, participation in research may offer an opportunity to contribute to meaningful medical advancements while receiving compassionate support from dedicated healthcare professionals.
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Aqualane Clinical Research
Memory Screening 3200 Bailey Lane, Naples, Florida, 34105HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. 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Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. 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Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDPrincipal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. 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Aqualane Clinical Research
Alzheimers Research 3200 Bailey Lane, Naples, Florida, 34105HistoryWith a combined 50+ years of clinical research, Dr. Justiz, Dr. Baker, and Kelly Calistri founded Aqualane Clinical Research in 2022. Since 2005, Dr. Justiz and Dr. Baker have been conducting studies together as Principal Investigators for their private practice. With a shared vision for a larger research institute, Kelly, a long-time consultant to the doctors, joined them in forming Aqualane Clinical Research.Message FromOur FoundersAt Aqualane, we always put our patients first.We promise to educate each potential participant and their family members on all options available to them and to support them in their decision-making process. Striving to make clinical trials a practical healthcare option, we provide a comfortable, caring and compassionate environment.Our founders are passionate about their contributions to the advancement of medicine and to the opportunities they provide to people searching for new treatment options. With expertise and experience in research and the central nervous system, you can trust our team of neurologists and researchers to provide the best possible opportunity for you or your loved one.OurTeamDr. William A. Justiz, MDMedical Director, Principal InvestigatorDr. William Justiz completed his undergraduate degree at Northwestern University before receiving his medical degree from the University of Miami School of Medicine. He is board certified in neurology and is a certified physician investigator through the Association of Clinical Research Professionals.With over 20 years of research experience and specialization in degenerative diseases of the nervous system, he has been in continuous practice in Naples, Florida since 1999. He is a founding member of the clinical research program that has grown into Aqualane Clinical Research.Community outreach and service is one of the core values of Dr. Justiz and Aqualane Clinical Research. Dr. Justiz demonstrates this with his 23-year commitment to providing low-cost or free services to epilepsy patients through Epilepsy Services of Southwest Florida. In addition, he has delivered a free educational lecture series every month on all Alzheimer's topics since 2015 through the Alzheimer's Support network.Kelly E. Calistri, B.A.Chief Operating Officer, Site DirectorKelly is a native Floridian, born and raised in Central Florida. Shortly before graduating from The University of Tennessee, Knoxville, with a degree in Psychology, she was introduced to the research industry. Almost immediately, she knew this would be her career path.While working at a privately owned clinical research site in Atlanta, she gained experience in several areas, including patient intake, research coordinator, regulatory, and cognitive rater. Working for years across many therapeutic areas, her passion for research grew. With this experience, Kelly received promotions into management roles. Her responsibilities included conducting training, oversight of a staff of 50 people, managing Phase I studies in a unit with 40 beds, and being responsible for business development by attending industry meetings to represent her site. Before opening Aqualane Clinical Research in 2022, she used her expertise and experience to build two startup research sites. Building a team of experts who excel in their field is among her strongest qualities. Her passion for people and the advancement of medicine drives her daily to continue learning. Kelly has seen how new medications can change the lives of people around her.In her free time, you can find Kelly and her husband, who are high school sweethearts, at local baseball fields cheering on their two sons. They are a close family who loves to travel and spend time together. Kelly also loves reading business and personal development books.Dr. Matthew J. Baker, MDPrincipal InvestigatorDr. Baker is a board-certified neurologist practicing for over 20 years. He has been a Principal Investigator in numerous clinical trials, many of which have resulted in regulatory approval of novel therapeutics across the spectrum of neurologic disease, both here and abroad. His primary areas of interest include Neuroimmunology, migraine, and the Neurobehavioral manifestations of disease. Dr. Baker is a nationally recognized educator and lecturer. He enjoys teaching colleagues, medical residents and patients on such topics as Multiple Sclerosis and Myasthenia Gravis. In his spare time, he loves riding roller coasters with this family and playing with his two dogs.Micaela M. Acres, RN, BSNInfusion NurseJacqueline E. BradyCommunity Outreach Coordinator/ ReceptionMatthew B. Cagney, B.S.Clinical Research CoordinatorElena Capron, B.S.Regulatory Coordinator / Social Media CoordinatorBrittany N. Cordero, B.S.Office Manager / Human ResourcesJessica M. DEntremont, RN, MPH, BSNInfusion NurseDarious T. Davis, M.A.Head of Business DevelopmentLaura Gold, B.S.Finance CoordinatorKarma L. Hamilton, M.S.Lead RaterBethany J.M. Henchesmoore, MBAClinical Research CoordinatorJennifer Jimenez-Perez, RN, BSNInfusion NurseCarmen L. Ojeda, M.S.Quality Assurance / Quality ControlMichelle A. O'Neill, M.S.RaterMayve SantosResearch PharmacistAlexandria L. SmithClinical Research Coordinator